TY - JOUR
T1 - Strength in numbers
T2 - cell penetrating peptide clusters to build next-generation therapeutics
AU - Reeman, Joseph
AU - Ittner, Lars M.
AU - Vallis, Katherine A.
AU - Tietz, Ole
PY - 2024/10/24
Y1 - 2024/10/24
N2 - The delivery of large molecules across biological barriers and into intracellular environments is one of the grand challenges of biomedical research. The recent development of cell penetrating peptide (CPP) clusters to transport antibodies, proteins, enzymes, and peptides across biological barriers at therapeutically relevant concentrations, marks a fundamental shift in our understanding of CPP functionality, providing a blueprint for crafting potent intracellular therapies. This review introduces the CPP clustering paradigm, delineates CPP clustering strategies and their effectiveness, highlights seminal contributions to the field, addresses challenges for the future, and summarises the clinical trial status of CPP therapeutics. Finally, we provide design guidelines for developing the next generation of CPP clusters and intracellular therapeutics, with a focus on translation into clinical practice.
AB - The delivery of large molecules across biological barriers and into intracellular environments is one of the grand challenges of biomedical research. The recent development of cell penetrating peptide (CPP) clusters to transport antibodies, proteins, enzymes, and peptides across biological barriers at therapeutically relevant concentrations, marks a fundamental shift in our understanding of CPP functionality, providing a blueprint for crafting potent intracellular therapies. This review introduces the CPP clustering paradigm, delineates CPP clustering strategies and their effectiveness, highlights seminal contributions to the field, addresses challenges for the future, and summarises the clinical trial status of CPP therapeutics. Finally, we provide design guidelines for developing the next generation of CPP clusters and intracellular therapeutics, with a focus on translation into clinical practice.
U2 - 10.1016/j.trechm.2024.09.003
DO - 10.1016/j.trechm.2024.09.003
M3 - Review article
SN - 2589-5974
JO - Trends in Chemistry
JF - Trends in Chemistry
ER -