Stress-induced mutation rates show a sigmoidal and saturable increase due to the RpoS sigma factor in Escherichia coli

Ram Maharjan, Thomas Ferenci

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Stress-induced mutagenesis was investigated in the absence of selection for growth fitness by using synthetic biology to control perceived environmental stress in Escherichia coli. We find that controlled intracellular RpoS dosage is central to a sigmoidal, saturable three- to fourfold increase in mutation rates and associated changes in DNA repair proteins.

Original languageEnglish
Pages (from-to)1231-1235
Number of pages5
JournalGenetics
Volume198
Issue number3
DOIs
Publication statusPublished - Nov 2014
Externally publishedYes

Keywords

  • Bacterial Proteins/metabolism
  • Escherichia coli/genetics
  • Gene Dosage
  • Intracellular Space/metabolism
  • Mutation Rate
  • Sigma Factor/metabolism
  • Stress, Physiological/genetics

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