STROKOG (stroke and cognition consortium): an international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

Perminder S. Sachdev, Jessica W. Lo, John D. Crawford, Lisa Mellon, Anne Hickey, David Williams, Régis Bordet, Anne-Marie Mendyk, Patrick Gelé, Dominique Deplanque, Hee-Joon Bae, Jae-Sung Lim, Amy Brodtmann, Emilio Werden, Toby B. Cumming, Sebastian Köhler, Frans R. J. Verhey, Yan-Hong Dong, Hui Hui Tan, Christopher ChenXu Xin, Raj N. Kalaria, Louise M Allan, Rufus O. Akinyemi, Adesola Ogunniyi, Aleksandra Klimkowicz-Mrowiec, Martin Dichgans, Frank A. Wollenweber, Vera Zietemann, Michael Hoffmann, David W. Desmond, Thomas Linden, Christian Blomstrand, Björn Fagerberg, Ingmar Skoog, Olivier Godefroy, Mélanie Barbay, Martine Roussel, Byung-Chul Lee, Kyung-Ho Yu, Joanna Wardlaw, Stephen J. Makin, Fergus N. Doubal, Francesca M. Chappell, Velandai K. Srikanth, Amanda G. Thrift, Geoffrey A. Donnan, Nagaendran Kandiah, Russell J. Chander, Xuling Lin, Charlotte Cordonnier, Solene Moulin, Costanza Rossi, Behnam Sabayan, David J. Stott, J. Wouter Jukema, Susanna Melkas, Hanna Jokinen, Timo Erkinjuntti, Vincent C. T. Mok, Adrian Wong, Bonnie Y. K. Lam, Didier Leys, Hilde Hénon, Stéphanie Bombois, Darren M. Lipnicki, Nicole A Kochan

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)
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Abstract

INTRODUCTION: The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD).

METHODS: Longitudinal studies with ≥75 participants who had suffered or were at risk of stroke or TIA and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia.

RESULTS: Currently, STROKOG includes 25 (21 published) studies, with 12,092 participants from five continents. The duration of follow-up ranges from 3 months to 21 years.

DISCUSSION: Although data harmonization will be a key challenge, STROKOG is in a unique position to reuse and combine international cohort data and fully explore patient level characteristics and outcomes. STROKOG could potentially transform our understanding of VCD and have a worldwide impact on promoting better vascular cognitive outcomes.

Original languageEnglish
Pages (from-to)11-23
Number of pages13
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume7
DOIs
Publication statusPublished - 2017
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • cohort studies
  • vascular dementia
  • post-stroke dementia
  • vascular cognitive disorder
  • small vessel disease
  • data harmonization
  • international consortium

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