TY - JOUR
T1 - Structural and dynamic characteristics in sonographic evaluation of the sciatic nerve in patients with probable neuropathic pain - A cross-sectional study
AU - Mainenti Pagnez, Maria Alice
AU - de Vilhena Moreira, Rayssa
AU - Martins do Rio, Jessica Pinto
AU - Corrêa, Leticia Amaral
AU - Mathieson, Stephanie
AU - Bittencourt, Juliana Valentim
AU - Nogueira, Leandro Calazans
PY - 2025/4
Y1 - 2025/4
N2 - Introduction: Structural and dynamic alterations of peripheral nerves are commonly observed in patients with radiculopathy. The current study aimed to compare the cross-sectional area (CSA), echogenicity index (ECHO), and skin-to-nerve distance (SKN) of the sciatic nerve between the symptomatic and asymptomatic sides of patients with probable neuropathic pain under different levels of nerve tension.Methods: A cross-sectional study was conducted with 31 participants classified as having probable chronic neuropathic pain. The CSA, ECHO, and SKN of the sciatic nerve of both lower limbs were measured in the following positions: A) flexed knee and neutral ankle, B) extended knee and ankle plantarflexion, and C) extended knee and ankle dorsiflexion. Sonographic measurements of both lower limbs were compared using repeated measures analysis of variance.Results: The mean age of the sample was 44 years (SD 10; 77.4% females), and the mean pain intensity was 5.3 (SD 1.9) out of 10 on the Numeric Pain Rating Scale. No significant differences were found for CSA, ECHO, or SKN measurements between the symptomatic and asymptomatic sides for the three tested positions. Position C had a smaller CSA of the sciatic nerve on both sides compared to position A. Both sides exhibited the nerve being more superficial in position C compared to the other positions.Conclusion: Participants with probable chronic neuropathic pain had similar CSA, ECHO, and SKN of the sciatic nerve between the symptomatic and asymptomatic lower limbs. Increasing sciatic nerve tension (position C) reduced CSA and caused superficial nerve displacement on both sides.
AB - Introduction: Structural and dynamic alterations of peripheral nerves are commonly observed in patients with radiculopathy. The current study aimed to compare the cross-sectional area (CSA), echogenicity index (ECHO), and skin-to-nerve distance (SKN) of the sciatic nerve between the symptomatic and asymptomatic sides of patients with probable neuropathic pain under different levels of nerve tension.Methods: A cross-sectional study was conducted with 31 participants classified as having probable chronic neuropathic pain. The CSA, ECHO, and SKN of the sciatic nerve of both lower limbs were measured in the following positions: A) flexed knee and neutral ankle, B) extended knee and ankle plantarflexion, and C) extended knee and ankle dorsiflexion. Sonographic measurements of both lower limbs were compared using repeated measures analysis of variance.Results: The mean age of the sample was 44 years (SD 10; 77.4% females), and the mean pain intensity was 5.3 (SD 1.9) out of 10 on the Numeric Pain Rating Scale. No significant differences were found for CSA, ECHO, or SKN measurements between the symptomatic and asymptomatic sides for the three tested positions. Position C had a smaller CSA of the sciatic nerve on both sides compared to position A. Both sides exhibited the nerve being more superficial in position C compared to the other positions.Conclusion: Participants with probable chronic neuropathic pain had similar CSA, ECHO, and SKN of the sciatic nerve between the symptomatic and asymptomatic lower limbs. Increasing sciatic nerve tension (position C) reduced CSA and caused superficial nerve displacement on both sides.
KW - Diagnostic Techniques and procedures
KW - Neuropathic pain
KW - Radiculopathy
KW - Sciatic nerve
KW - Sciatica
KW - Spine-related leg pain
KW - Ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=85216639591&partnerID=8YFLogxK
U2 - 10.1016/j.msksp.2025.103272
DO - 10.1016/j.msksp.2025.103272
M3 - Article
C2 - 39908891
SN - 2468-8630
VL - 76
SP - 1
EP - 8
JO - Musculoskeletal Science & Practice
JF - Musculoskeletal Science & Practice
M1 - 103272
ER -