Structure-based clustering of major histocompatibility complex (MHC) proteins for broad-based T-cell vaccine design

Joo Chuan Tong; Tin Wee Tan; Shoba Ranganathan

doi:10.1007/978-1-4939-1115-8_27

Structure-based clustering of major histocompatibility complex (MHC) proteins for broad-based T-cell vaccine design

Joo Chuan Tong^*, Tin Wee Tan, Shoba Ranganathan

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Structure-based clustering technique is useful for identifying superfamilies of major histocompatibility complex (MHC) proteins with similar binding specificities. The resolved MHC superfamilies play an important role in vaccine development, from discovering new targets for broad-based vaccines and therapeutics to optimizing the affinity and selectivity of hits. Here, we describe a protocol and provide a summary for grouping MHC proteins according to their structural interaction characteristics.

Original language	English
Title of host publication	Immunoinformatics
Editors	Rajat K. De, Namrata Tomar
Place of Publication	New York
Publisher	Humana Press
Pages	503-511
Number of pages	9
Edition	2nd
ISBN (Electronic)	9781493911158
ISBN (Print)	9781493911141
DOIs	https://doi.org/10.1007/978-1-4939-1115-8_27
Publication status	Published - 2014

Publication series

Name	Methods in Molecular Biology
Volume	1184
ISSN (Print)	1064-3745

Keywords

Bioinformatics
Clustering
Computer-aided vaccine design
Immunoinformatics
MHC superfamily
Virtual screening

Access to Document

10.1007/978-1-4939-1115-8_27

Cite this

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abstract = "Structure-based clustering technique is useful for identifying superfamilies of major histocompatibility complex (MHC) proteins with similar binding specificities. The resolved MHC superfamilies play an important role in vaccine development, from discovering new targets for broad-based vaccines and therapeutics to optimizing the affinity and selectivity of hits. Here, we describe a protocol and provide a summary for grouping MHC proteins according to their structural interaction characteristics.",

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Structure-based clustering of major histocompatibility complex (MHC) proteins for broad-based T-cell vaccine design. / Tong, Joo Chuan; Tan, Tin Wee; Ranganathan, Shoba.
Immunoinformatics. ed. / Rajat K. De; Namrata Tomar. 2nd. ed. New York: Humana Press, 2014. p. 503-511 (Methods in Molecular Biology; Vol. 1184).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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AU - Tan, Tin Wee

AU - Ranganathan, Shoba

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KW - Clustering

KW - Computer-aided vaccine design

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KW - Virtual screening

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Structure-based clustering of major histocompatibility complex (MHC) proteins for broad-based T-cell vaccine design

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