Structure-based clustering of major histocompatibility complex (MHC) proteins for broad-based T-cell vaccine design

Joo Chuan Tong, Tin Wee Tan, Shoba Ranganathan

Research output: Chapter in Book/Report/Conference proceedingChapterResearch

Abstract

Structure-based clustering technique is useful for identifying superfamilies of major histocompatibility complex (MHC) proteins with similar binding specificities. The resolved MHC superfamilies play an important role in vaccine development, from discovering new targets for broad-based vaccines and therapeutics to optimizing the affinity and selectivity of hits. Here, we describe a protocol and provide a summary for grouping MHC proteins according to their structural interaction characteristics.

LanguageEnglish
Title of host publicationImmunoinformatics
EditorsRajat K. De, Namrata Tomar
Place of PublicationNew York
PublisherHumana Press
Pages503-511
Number of pages9
Edition2nd
ISBN (Electronic)9781493911158
ISBN (Print)9781493911141
DOIs
Publication statusPublished - 2014

Publication series

NameMethods in Molecular Biology
Volume1184
ISSN (Print)1064-3745

Fingerprint

Major Histocompatibility Complex
Cluster Analysis
Vaccines
T-Lymphocytes
Proteins
Therapeutics

Cite this

Tong, J. C., Tan, T. W., & Ranganathan, S. (2014). Structure-based clustering of major histocompatibility complex (MHC) proteins for broad-based T-cell vaccine design. In R. K. De, & N. Tomar (Eds.), Immunoinformatics (2nd ed., pp. 503-511). (Methods in Molecular Biology; Vol. 1184). New York: Humana Press. https://doi.org/10.1007/978-1-4939-1115-8_27
Tong, Joo Chuan ; Tan, Tin Wee ; Ranganathan, Shoba. / Structure-based clustering of major histocompatibility complex (MHC) proteins for broad-based T-cell vaccine design. Immunoinformatics. editor / Rajat K. De ; Namrata Tomar. 2nd. ed. New York : Humana Press, 2014. pp. 503-511 (Methods in Molecular Biology).
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Tong, JC, Tan, TW & Ranganathan, S 2014, Structure-based clustering of major histocompatibility complex (MHC) proteins for broad-based T-cell vaccine design. in RK De & N Tomar (eds), Immunoinformatics. 2nd edn, Methods in Molecular Biology, vol. 1184, Humana Press, New York, pp. 503-511. https://doi.org/10.1007/978-1-4939-1115-8_27

Structure-based clustering of major histocompatibility complex (MHC) proteins for broad-based T-cell vaccine design. / Tong, Joo Chuan; Tan, Tin Wee; Ranganathan, Shoba.

Immunoinformatics. ed. / Rajat K. De; Namrata Tomar. 2nd. ed. New York : Humana Press, 2014. p. 503-511 (Methods in Molecular Biology; Vol. 1184).

Research output: Chapter in Book/Report/Conference proceedingChapterResearch

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Tong JC, Tan TW, Ranganathan S. Structure-based clustering of major histocompatibility complex (MHC) proteins for broad-based T-cell vaccine design. In De RK, Tomar N, editors, Immunoinformatics. 2nd ed. New York: Humana Press. 2014. p. 503-511. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-1115-8_27