Structure-based clustering of major histocompatibility complex (MHC) proteins for broad-based T-cell vaccine design

Joo Chuan Tong*, Tin Wee Tan, Shoba Ranganathan

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Structure-based clustering technique is useful for identifying superfamilies of major histocompatibility complex (MHC) proteins with similar binding specificities. The resolved MHC superfamilies play an important role in vaccine development, from discovering new targets for broad-based vaccines and therapeutics to optimizing the affinity and selectivity of hits. Here, we describe a protocol and provide a summary for grouping MHC proteins according to their structural interaction characteristics.

Original languageEnglish
Title of host publicationImmunoinformatics
EditorsRajat K. De, Namrata Tomar
Place of PublicationNew York
PublisherHumana Press
Pages503-511
Number of pages9
Edition2nd
ISBN (Electronic)9781493911158
ISBN (Print)9781493911141
DOIs
Publication statusPublished - 2014

Publication series

NameMethods in Molecular Biology
Volume1184
ISSN (Print)1064-3745

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