Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults

Belinda M. Brown; Stephanie R. Rainey-Smith; Natalie Castalanelli; Nicole Gordon; Shaun Markovic; Hamid R. Sohrabi; Michael Weinborn; Simon M. Laws; James Doecke; Kaikai Shen; Ralph N. Martins; Jeremiah J. Peiffer

doi:10.1016/j.trci.2017.09.003

Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults

Belinda M. Brown^*, Stephanie R. Rainey-Smith, Natalie Castalanelli, Nicole Gordon, Shaun Markovic, Hamid R. Sohrabi, Michael Weinborn, Simon M. Laws, James Doecke, Kaikai Shen, Ralph N. Martins, Jeremiah J. Peiffer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

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Abstract

Introduction: Inconsistent results from previous studies of exercise and cognitive function suggest that rigorously designed randomized controlled trials are urgently needed. Here, we describe the design of the Intense Physical Activity and Cognition (IPAC) study, which will assess the impact of a 6-month high-intensity exercise intervention on cognitive function and biomarkers of dementia risk, compared with a 6-month moderate-intensity exercise intervention and control group (no study-related exercise).

Methods: One-hundred and five cognitively healthy men and women aged between 60 and 80 years are randomized into a high-intensity exercise, moderate-intensity exercise, or control group. Individuals randomized to an exercise intervention undertake 6 months of cycle-based exercise twice a week, at 50 minutes per session. All participants undergo comprehensive neuropsychological testing, blood sampling, brain magnetic resonance imaging, fitness testing, and a body composition scan at baseline, 6 months (immediately after intervention), and 18 months (12 months after intervention).

Discussion: The IPAC study takes a multidisciplinary approach to investigating the role of exercise in maintaining a healthy brain throughout aging. Rigorous monitoring of exertion and adherence throughout the intervention, combined with repeated measures of fitness, is vital in ensuring an optimum exercise dose is reached. Results from the IPAC study will be used to inform a large-scale multicentre randomized controlled trial, with the ultimate aim of pinpointing the frequency, duration, and intensity of exercise that provides the most benefit to the brain, in terms of enhancing cognitive function and reducing dementia risk in older adults.

Original language	English
Pages (from-to)	562-570
Number of pages	9
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/j.trci.2017.09.003
Publication status	Published - 1 Nov 2017

Bibliographical note

Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

cognition
dementia
exercise
intervention
study design

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10.1016/j.trci.2017.09.003

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Cite this

Brown, B. M., Rainey-Smith, S. R., Castalanelli, N., Gordon, N., Markovic, S., Sohrabi, H. R., Weinborn, M., Laws, S. M., Doecke, J., Shen, K., Martins, R. N., & Peiffer, J. J. (2017). Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 3(4), 562-570. https://doi.org/10.1016/j.trci.2017.09.003

@article{03e78f2a133e4e4ba4742d9b210e0ea7,

title = "Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults",

abstract = "Introduction: Inconsistent results from previous studies of exercise and cognitive function suggest that rigorously designed randomized controlled trials are urgently needed. Here, we describe the design of the Intense Physical Activity and Cognition (IPAC) study, which will assess the impact of a 6-month high-intensity exercise intervention on cognitive function and biomarkers of dementia risk, compared with a 6-month moderate-intensity exercise intervention and control group (no study-related exercise). Methods: One-hundred and five cognitively healthy men and women aged between 60 and 80 years are randomized into a high-intensity exercise, moderate-intensity exercise, or control group. Individuals randomized to an exercise intervention undertake 6 months of cycle-based exercise twice a week, at 50 minutes per session. All participants undergo comprehensive neuropsychological testing, blood sampling, brain magnetic resonance imaging, fitness testing, and a body composition scan at baseline, 6 months (immediately after intervention), and 18 months (12 months after intervention). Discussion: The IPAC study takes a multidisciplinary approach to investigating the role of exercise in maintaining a healthy brain throughout aging. Rigorous monitoring of exertion and adherence throughout the intervention, combined with repeated measures of fitness, is vital in ensuring an optimum exercise dose is reached. Results from the IPAC study will be used to inform a large-scale multicentre randomized controlled trial, with the ultimate aim of pinpointing the frequency, duration, and intensity of exercise that provides the most benefit to the brain, in terms of enhancing cognitive function and reducing dementia risk in older adults.",

keywords = "cognition, dementia, exercise, intervention, study design",

author = "Brown, \{Belinda M.\} and Rainey-Smith, \{Stephanie R.\} and Natalie Castalanelli and Nicole Gordon and Shaun Markovic and Sohrabi, \{Hamid R.\} and Michael Weinborn and Laws, \{Simon M.\} and James Doecke and Kaikai Shen and Martins, \{Ralph N.\} and Peiffer, \{Jeremiah J.\}",

note = "Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2017",

month = nov,

day = "1",

doi = "10.1016/j.trci.2017.09.003",

language = "English",

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journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",

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Brown, BM, Rainey-Smith, SR, Castalanelli, N, Gordon, N, Markovic, S, Sohrabi, HR, Weinborn, M, Laws, SM, Doecke, J, Shen, K, Martins, RN & Peiffer, JJ 2017, 'Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 3, no. 4, pp. 562-570. https://doi.org/10.1016/j.trci.2017.09.003

Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults. / Brown, Belinda M.; Rainey-Smith, Stephanie R.; Castalanelli, Natalie et al.
In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 3, No. 4, 01.11.2017, p. 562-570.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Study protocol of the Intense Physical Activity and Cognition study

T2 - The effect of high-intensity exercise training on cognitive function in older adults

AU - Brown, Belinda M.

AU - Rainey-Smith, Stephanie R.

AU - Castalanelli, Natalie

AU - Gordon, Nicole

AU - Markovic, Shaun

AU - Sohrabi, Hamid R.

AU - Weinborn, Michael

AU - Laws, Simon M.

AU - Doecke, James

AU - Shen, Kaikai

AU - Martins, Ralph N.

AU - Peiffer, Jeremiah J.

N1 - Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Introduction: Inconsistent results from previous studies of exercise and cognitive function suggest that rigorously designed randomized controlled trials are urgently needed. Here, we describe the design of the Intense Physical Activity and Cognition (IPAC) study, which will assess the impact of a 6-month high-intensity exercise intervention on cognitive function and biomarkers of dementia risk, compared with a 6-month moderate-intensity exercise intervention and control group (no study-related exercise). Methods: One-hundred and five cognitively healthy men and women aged between 60 and 80 years are randomized into a high-intensity exercise, moderate-intensity exercise, or control group. Individuals randomized to an exercise intervention undertake 6 months of cycle-based exercise twice a week, at 50 minutes per session. All participants undergo comprehensive neuropsychological testing, blood sampling, brain magnetic resonance imaging, fitness testing, and a body composition scan at baseline, 6 months (immediately after intervention), and 18 months (12 months after intervention). Discussion: The IPAC study takes a multidisciplinary approach to investigating the role of exercise in maintaining a healthy brain throughout aging. Rigorous monitoring of exertion and adherence throughout the intervention, combined with repeated measures of fitness, is vital in ensuring an optimum exercise dose is reached. Results from the IPAC study will be used to inform a large-scale multicentre randomized controlled trial, with the ultimate aim of pinpointing the frequency, duration, and intensity of exercise that provides the most benefit to the brain, in terms of enhancing cognitive function and reducing dementia risk in older adults.

AB - Introduction: Inconsistent results from previous studies of exercise and cognitive function suggest that rigorously designed randomized controlled trials are urgently needed. Here, we describe the design of the Intense Physical Activity and Cognition (IPAC) study, which will assess the impact of a 6-month high-intensity exercise intervention on cognitive function and biomarkers of dementia risk, compared with a 6-month moderate-intensity exercise intervention and control group (no study-related exercise). Methods: One-hundred and five cognitively healthy men and women aged between 60 and 80 years are randomized into a high-intensity exercise, moderate-intensity exercise, or control group. Individuals randomized to an exercise intervention undertake 6 months of cycle-based exercise twice a week, at 50 minutes per session. All participants undergo comprehensive neuropsychological testing, blood sampling, brain magnetic resonance imaging, fitness testing, and a body composition scan at baseline, 6 months (immediately after intervention), and 18 months (12 months after intervention). Discussion: The IPAC study takes a multidisciplinary approach to investigating the role of exercise in maintaining a healthy brain throughout aging. Rigorous monitoring of exertion and adherence throughout the intervention, combined with repeated measures of fitness, is vital in ensuring an optimum exercise dose is reached. Results from the IPAC study will be used to inform a large-scale multicentre randomized controlled trial, with the ultimate aim of pinpointing the frequency, duration, and intensity of exercise that provides the most benefit to the brain, in terms of enhancing cognitive function and reducing dementia risk in older adults.

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KW - dementia

KW - exercise

KW - intervention

KW - study design

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DO - 10.1016/j.trci.2017.09.003

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Brown BM, Rainey-Smith SR, Castalanelli N, Gordon N, Markovic S, Sohrabi HR et al. Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults. Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2017 Nov 1;3(4):562-570. doi: 10.1016/j.trci.2017.09.003

Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults

Abstract

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