Subjective memory complaints predict baseline but not future cognitive function over three years: results from the Western Australia Memory Study

Hamid R. Sohrabi; Michael Weinborn; Christoph Laske; Kristyn A. Bates; Daniel Christensen; Kevin Taddei; Stephanie R. Rainey-Smith; Belinda M. Brown; Samantha L. Gardener,; Simon M. Laws; Georgia  Martins; Samantha C. Burnham; Romola S. Bucks; Barry Reisberg; Nicola T.  Lautenschlager; Jonathan Foster; Ralph N. Martins

doi:10.1017/S1041610218001072

Subjective memory complaints predict baseline but not future cognitive function over three years: results from the Western Australia Memory Study

Hamid R. Sohrabi, Michael Weinborn, Christoph Laske, Kristyn A. Bates, Daniel Christensen, Kevin Taddei, Stephanie R. Rainey-Smith, Belinda M. Brown, Samantha L. Gardener,, Simon M. Laws, Georgia Martins, Samantha C. Burnham, Romola S. Bucks, Barry Reisberg, Nicola T. Lautenschlager, Jonathan Foster, Ralph N. Martins

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Background: This study investigated the characteristics of subjective memory complaints (SMCs) and their association with current and future cognitive functions.

Methods: A cohort of 209 community-dwelling individuals without dementia aged 47–90 years old was recruited for this 3-year study. Participants underwent neuropsychological and clinical assessments annually. Participants were divided into SMCs and non-memory complainers (NMCs) using a single question at baseline and a memory complaints questionnaire following baseline, to evaluate differential patterns of complaints. In addition, comprehensive assessment of memory complaints was undertaken to evaluate whether severity and consistency of complaints differentially predicted cognitive function.

Results: SMC and NMC individuals were significantly different on various features of SMCs. Greater overall severity (but not consistency) of complaints was significantly associated with current and future cognitive functioning.

Conclusions: SMC individuals present distinctive features of memory complaints as compared to NMCs. Further, the severity of complaints was a significant predictor of future cognition. However, SMC did not significantly predict change over time in this sample. These findings warrant further research into the specific features of SMCs that may portend subsequent neuropathological and cognitive changes when screening individuals at increased future risk of dementia.

Original language	English
Pages (from-to)	513-525
Number of pages	13
Journal	International Psychogeriatrics
Volume	31
Issue number	4
Early online date	2 Oct 2018
DOIs	https://doi.org/10.1017/S1041610218001072
Publication status	Published - 1 Apr 2019

Keywords

Alzheimer's disease
MFQ
apolipoprotein E
cognitive decline
dementia
depression
subjective memory complaints

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Sohrabi, H. R., Weinborn, M., Laske, C., Bates, K. A., Christensen, D., Taddei, K., Rainey-Smith, S. R., Brown, B. M., Gardener, S. L., Laws, S. M., Martins, G., Burnham, S. C., Bucks, R. S., Reisberg, B., Lautenschlager, N. T., Foster, J., & Martins, R. N. (2019). Subjective memory complaints predict baseline but not future cognitive function over three years: results from the Western Australia Memory Study. International Psychogeriatrics, 31(4), 513-525. https://doi.org/10.1017/S1041610218001072

@article{d14a20be56be4d3881fd8857c935dd7e,

title = "Subjective memory complaints predict baseline but not future cognitive function over three years: results from the Western Australia Memory Study",

abstract = "Background: This study investigated the characteristics of subjective memory complaints (SMCs) and their association with current and future cognitive functions. Methods: A cohort of 209 community-dwelling individuals without dementia aged 47–90 years old was recruited for this 3-year study. Participants underwent neuropsychological and clinical assessments annually. Participants were divided into SMCs and non-memory complainers (NMCs) using a single question at baseline and a memory complaints questionnaire following baseline, to evaluate differential patterns of complaints. In addition, comprehensive assessment of memory complaints was undertaken to evaluate whether severity and consistency of complaints differentially predicted cognitive function. Results: SMC and NMC individuals were significantly different on various features of SMCs. Greater overall severity (but not consistency) of complaints was significantly associated with current and future cognitive functioning. Conclusions: SMC individuals present distinctive features of memory complaints as compared to NMCs. Further, the severity of complaints was a significant predictor of future cognition. However, SMC did not significantly predict change over time in this sample. These findings warrant further research into the specific features of SMCs that may portend subsequent neuropathological and cognitive changes when screening individuals at increased future risk of dementia.",

keywords = "Alzheimer's disease, MFQ, apolipoprotein E, cognitive decline, dementia, depression, subjective memory complaints",

author = "Sohrabi, \{Hamid R.\} and Michael Weinborn and Christoph Laske and Bates, \{Kristyn A.\} and Daniel Christensen and Kevin Taddei and Rainey-Smith, \{Stephanie R.\} and Brown, \{Belinda M.\} and Gardener,, \{Samantha L.\} and Laws, \{Simon M.\} and Georgia Martins and Burnham, \{Samantha C.\} and Bucks, \{Romola S.\} and Barry Reisberg and Lautenschlager, \{Nicola T.\} and Jonathan Foster and Martins, \{Ralph N.\}",

year = "2019",

month = apr,

day = "1",

doi = "10.1017/S1041610218001072",

language = "English",

volume = "31",

pages = "513--525",

journal = "International Psychogeriatrics",

issn = "1041-6102",

publisher = "Elsevier",

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Sohrabi, HR, Weinborn, M, Laske, C, Bates, KA, Christensen, D, Taddei, K, Rainey-Smith, SR, Brown, BM, Gardener, SL, Laws, SM, Martins, G, Burnham, SC, Bucks, RS, Reisberg, B, Lautenschlager, NT, Foster, J & Martins, RN 2019, 'Subjective memory complaints predict baseline but not future cognitive function over three years: results from the Western Australia Memory Study', International Psychogeriatrics, vol. 31, no. 4, pp. 513-525. https://doi.org/10.1017/S1041610218001072

TY - JOUR

T1 - Subjective memory complaints predict baseline but not future cognitive function over three years

T2 - results from the Western Australia Memory Study

AU - Sohrabi, Hamid R.

AU - Weinborn, Michael

AU - Laske, Christoph

AU - Bates, Kristyn A.

AU - Christensen, Daniel

AU - Taddei, Kevin

AU - Rainey-Smith, Stephanie R.

AU - Brown, Belinda M.

AU - Gardener,, Samantha L.

AU - Laws, Simon M.

AU - Martins, Georgia

AU - Burnham, Samantha C.

AU - Bucks, Romola S.

AU - Reisberg, Barry

AU - Lautenschlager, Nicola T.

AU - Foster, Jonathan

AU - Martins, Ralph N.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Background: This study investigated the characteristics of subjective memory complaints (SMCs) and their association with current and future cognitive functions. Methods: A cohort of 209 community-dwelling individuals without dementia aged 47–90 years old was recruited for this 3-year study. Participants underwent neuropsychological and clinical assessments annually. Participants were divided into SMCs and non-memory complainers (NMCs) using a single question at baseline and a memory complaints questionnaire following baseline, to evaluate differential patterns of complaints. In addition, comprehensive assessment of memory complaints was undertaken to evaluate whether severity and consistency of complaints differentially predicted cognitive function. Results: SMC and NMC individuals were significantly different on various features of SMCs. Greater overall severity (but not consistency) of complaints was significantly associated with current and future cognitive functioning. Conclusions: SMC individuals present distinctive features of memory complaints as compared to NMCs. Further, the severity of complaints was a significant predictor of future cognition. However, SMC did not significantly predict change over time in this sample. These findings warrant further research into the specific features of SMCs that may portend subsequent neuropathological and cognitive changes when screening individuals at increased future risk of dementia.

AB - Background: This study investigated the characteristics of subjective memory complaints (SMCs) and their association with current and future cognitive functions. Methods: A cohort of 209 community-dwelling individuals without dementia aged 47–90 years old was recruited for this 3-year study. Participants underwent neuropsychological and clinical assessments annually. Participants were divided into SMCs and non-memory complainers (NMCs) using a single question at baseline and a memory complaints questionnaire following baseline, to evaluate differential patterns of complaints. In addition, comprehensive assessment of memory complaints was undertaken to evaluate whether severity and consistency of complaints differentially predicted cognitive function. Results: SMC and NMC individuals were significantly different on various features of SMCs. Greater overall severity (but not consistency) of complaints was significantly associated with current and future cognitive functioning. Conclusions: SMC individuals present distinctive features of memory complaints as compared to NMCs. Further, the severity of complaints was a significant predictor of future cognition. However, SMC did not significantly predict change over time in this sample. These findings warrant further research into the specific features of SMCs that may portend subsequent neuropathological and cognitive changes when screening individuals at increased future risk of dementia.

KW - Alzheimer's disease

KW - MFQ

KW - apolipoprotein E

KW - cognitive decline

KW - dementia

KW - depression

KW - subjective memory complaints

UR - https://www.scopus.com/pages/publications/85055006402

U2 - 10.1017/S1041610218001072

DO - 10.1017/S1041610218001072

M3 - Article

C2 - 30277188

SN - 1041-6102

VL - 31

SP - 513

EP - 525

JO - International Psychogeriatrics

JF - International Psychogeriatrics

IS - 4

ER -

Subjective memory complaints predict baseline but not future cognitive function over three years: results from the Western Australia Memory Study

Abstract

Keywords

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