Submicron polyacrolein particles in situ embedded with upconversion nanoparticles for bioassay

A. N. Generalova; I. K. Kochneva; E. V. Khaydukov; V. A. Semchishen; A. E. Guller; A. V. Nechaev; A. B. Shekhter; V. P. Zubov; A. V. Zvyagin; S. M. Deyev

doi:10.1039/c4nr05908e

Submicron polyacrolein particles in situ embedded with upconversion nanoparticles for bioassay

A. N. Generalova, I. K. Kochneva, E. V. Khaydukov, V. A. Semchishen, A. E. Guller, A. V. Nechaev, A. B. Shekhter, V. P. Zubov, A. V. Zvyagin^*, S. M. Deyev

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

We report a new surface modification approach of upconversion nanoparticles (UCNPs) structured as inorganic hosts NaYF₄ codoped with Yb³⁺ and Er³⁺ based on their encapsulation in a two-stage process of precipitation polymerization of acrolein under alkaline conditions in the presence of UCNPs. The use of tetramethylammonium hydroxide both as an initiator of acrolein polymerization and as an agent for UCNP hydrophilization made it possible to increase the polyacrolein yield up to 90%. This approach enabled the facile, lossless embedment of UCNPs into the polymer particles suitable for bioassay. These particles are readily dispersible in aqueous and physiological buffers, exhibiting excellent photoluminescence properties, chemical stability, and also allow the control of particle diameters. The feasibility of the as-produced photoluminescent polymer particles mean-sized 260 nm for in vivo optical whole-animal imaging was also demonstrated using a home-built epi-luminescence imaging system.

Original language	English
Pages (from-to)	1709-1717
Number of pages	9
Journal	Nanoscale
Volume	7
Issue number	5
DOIs	https://doi.org/10.1039/c4nr05908e
Publication status	Published - 7 Feb 2015

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title = "Submicron polyacrolein particles in situ embedded with upconversion nanoparticles for bioassay",

abstract = "We report a new surface modification approach of upconversion nanoparticles (UCNPs) structured as inorganic hosts NaYF4 codoped with Yb3+ and Er3+ based on their encapsulation in a two-stage process of precipitation polymerization of acrolein under alkaline conditions in the presence of UCNPs. The use of tetramethylammonium hydroxide both as an initiator of acrolein polymerization and as an agent for UCNP hydrophilization made it possible to increase the polyacrolein yield up to 90%. This approach enabled the facile, lossless embedment of UCNPs into the polymer particles suitable for bioassay. These particles are readily dispersible in aqueous and physiological buffers, exhibiting excellent photoluminescence properties, chemical stability, and also allow the control of particle diameters. The feasibility of the as-produced photoluminescent polymer particles mean-sized 260 nm for in vivo optical whole-animal imaging was also demonstrated using a home-built epi-luminescence imaging system.",

author = "Generalova, {A. N.} and Kochneva, {I. K.} and Khaydukov, {E. V.} and Semchishen, {V. A.} and Guller, {A. E.} and Nechaev, {A. V.} and Shekhter, {A. B.} and Zubov, {V. P.} and Zvyagin, {A. V.} and Deyev, {S. M.}",

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AU - Generalova, A. N.

AU - Kochneva, I. K.

AU - Khaydukov, E. V.

AU - Semchishen, V. A.

AU - Guller, A. E.

AU - Nechaev, A. V.

AU - Shekhter, A. B.

AU - Zubov, V. P.

AU - Zvyagin, A. V.

AU - Deyev, S. M.

PY - 2015/2/7

Y1 - 2015/2/7

N2 - We report a new surface modification approach of upconversion nanoparticles (UCNPs) structured as inorganic hosts NaYF4 codoped with Yb3+ and Er3+ based on their encapsulation in a two-stage process of precipitation polymerization of acrolein under alkaline conditions in the presence of UCNPs. The use of tetramethylammonium hydroxide both as an initiator of acrolein polymerization and as an agent for UCNP hydrophilization made it possible to increase the polyacrolein yield up to 90%. This approach enabled the facile, lossless embedment of UCNPs into the polymer particles suitable for bioassay. These particles are readily dispersible in aqueous and physiological buffers, exhibiting excellent photoluminescence properties, chemical stability, and also allow the control of particle diameters. The feasibility of the as-produced photoluminescent polymer particles mean-sized 260 nm for in vivo optical whole-animal imaging was also demonstrated using a home-built epi-luminescence imaging system.

AB - We report a new surface modification approach of upconversion nanoparticles (UCNPs) structured as inorganic hosts NaYF4 codoped with Yb3+ and Er3+ based on their encapsulation in a two-stage process of precipitation polymerization of acrolein under alkaline conditions in the presence of UCNPs. The use of tetramethylammonium hydroxide both as an initiator of acrolein polymerization and as an agent for UCNP hydrophilization made it possible to increase the polyacrolein yield up to 90%. This approach enabled the facile, lossless embedment of UCNPs into the polymer particles suitable for bioassay. These particles are readily dispersible in aqueous and physiological buffers, exhibiting excellent photoluminescence properties, chemical stability, and also allow the control of particle diameters. The feasibility of the as-produced photoluminescent polymer particles mean-sized 260 nm for in vivo optical whole-animal imaging was also demonstrated using a home-built epi-luminescence imaging system.

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VL - 7

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EP - 1717

JO - Nanoscale

JF - Nanoscale

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ER -

Submicron polyacrolein particles in situ embedded with upconversion nanoparticles for bioassay

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