Substance P inputs to laryngeal motoneurons in the rat

Qi Jian Sun; Robert G. Berkowitz; Ann K. Goodchild; Paul M. Pilowsky

doi:10.1016/S1569-9048(03)00136-8

Substance P inputs to laryngeal motoneurons in the rat

Qi Jian Sun, Robert G. Berkowitz, Ann K. Goodchild, Paul M. Pilowsky^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Substance P terminals have previously been demonstrated around retrogradely labelled posterior cricoarytenoid (PCA) motoneurons, but little is known regarding substance P inputs to other functionally identified laryngeal motoneurons. In the present study, we determined the number and distribution of close appositions between substance P immunoreactive boutons and three types of laryngeal motoneuron by using a combination of intracellular recording, dye-filling and immunocytochemistry in the rat. Cricothyroid (CT) motoneurons received 15±5 substance P appositions/neuron (mean±S.D., n=6), PCA motoneurons received 13±5 (n=6), and laryngeal constrictor (LCS) motoneurons received 11±4 (n=5). In contrast to our previous finding of a preferential serotonin innervation of CT motoneurons, we found no significant difference between the substance P inputs to CT, PCA and LCS motoneurons. Our results indicate a modest role for substance P in control of laryngeal motoneuronal function.

Original language	English
Pages (from-to)	11-18
Number of pages	8
Journal	Respiratory Physiology and Neurobiology
Volume	137
Issue number	1
DOIs	https://doi.org/10.1016/S1569-9048(03)00136-8
Publication status	Published - 14 Aug 2003
Externally published	Yes

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title = "Substance P inputs to laryngeal motoneurons in the rat",

abstract = "Substance P terminals have previously been demonstrated around retrogradely labelled posterior cricoarytenoid (PCA) motoneurons, but little is known regarding substance P inputs to other functionally identified laryngeal motoneurons. In the present study, we determined the number and distribution of close appositions between substance P immunoreactive boutons and three types of laryngeal motoneuron by using a combination of intracellular recording, dye-filling and immunocytochemistry in the rat. Cricothyroid (CT) motoneurons received 15±5 substance P appositions/neuron (mean±S.D., n=6), PCA motoneurons received 13±5 (n=6), and laryngeal constrictor (LCS) motoneurons received 11±4 (n=5). In contrast to our previous finding of a preferential serotonin innervation of CT motoneurons, we found no significant difference between the substance P inputs to CT, PCA and LCS motoneurons. Our results indicate a modest role for substance P in control of laryngeal motoneuronal function.",

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AU - Sun, Qi Jian

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AU - Goodchild, Ann K.

AU - Pilowsky, Paul M.

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N2 - Substance P terminals have previously been demonstrated around retrogradely labelled posterior cricoarytenoid (PCA) motoneurons, but little is known regarding substance P inputs to other functionally identified laryngeal motoneurons. In the present study, we determined the number and distribution of close appositions between substance P immunoreactive boutons and three types of laryngeal motoneuron by using a combination of intracellular recording, dye-filling and immunocytochemistry in the rat. Cricothyroid (CT) motoneurons received 15±5 substance P appositions/neuron (mean±S.D., n=6), PCA motoneurons received 13±5 (n=6), and laryngeal constrictor (LCS) motoneurons received 11±4 (n=5). In contrast to our previous finding of a preferential serotonin innervation of CT motoneurons, we found no significant difference between the substance P inputs to CT, PCA and LCS motoneurons. Our results indicate a modest role for substance P in control of laryngeal motoneuronal function.

AB - Substance P terminals have previously been demonstrated around retrogradely labelled posterior cricoarytenoid (PCA) motoneurons, but little is known regarding substance P inputs to other functionally identified laryngeal motoneurons. In the present study, we determined the number and distribution of close appositions between substance P immunoreactive boutons and three types of laryngeal motoneuron by using a combination of intracellular recording, dye-filling and immunocytochemistry in the rat. Cricothyroid (CT) motoneurons received 15±5 substance P appositions/neuron (mean±S.D., n=6), PCA motoneurons received 13±5 (n=6), and laryngeal constrictor (LCS) motoneurons received 11±4 (n=5). In contrast to our previous finding of a preferential serotonin innervation of CT motoneurons, we found no significant difference between the substance P inputs to CT, PCA and LCS motoneurons. Our results indicate a modest role for substance P in control of laryngeal motoneuronal function.

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