TY - JOUR
T1 - Substance P inputs to laryngeal motoneurons in the rat
AU - Sun, Qi Jian
AU - Berkowitz, Robert G.
AU - Goodchild, Ann K.
AU - Pilowsky, Paul M.
PY - 2003/8/14
Y1 - 2003/8/14
N2 - Substance P terminals have previously been demonstrated around retrogradely labelled posterior cricoarytenoid (PCA) motoneurons, but little is known regarding substance P inputs to other functionally identified laryngeal motoneurons. In the present study, we determined the number and distribution of close appositions between substance P immunoreactive boutons and three types of laryngeal motoneuron by using a combination of intracellular recording, dye-filling and immunocytochemistry in the rat. Cricothyroid (CT) motoneurons received 15±5 substance P appositions/neuron (mean±S.D., n=6), PCA motoneurons received 13±5 (n=6), and laryngeal constrictor (LCS) motoneurons received 11±4 (n=5). In contrast to our previous finding of a preferential serotonin innervation of CT motoneurons, we found no significant difference between the substance P inputs to CT, PCA and LCS motoneurons. Our results indicate a modest role for substance P in control of laryngeal motoneuronal function.
AB - Substance P terminals have previously been demonstrated around retrogradely labelled posterior cricoarytenoid (PCA) motoneurons, but little is known regarding substance P inputs to other functionally identified laryngeal motoneurons. In the present study, we determined the number and distribution of close appositions between substance P immunoreactive boutons and three types of laryngeal motoneuron by using a combination of intracellular recording, dye-filling and immunocytochemistry in the rat. Cricothyroid (CT) motoneurons received 15±5 substance P appositions/neuron (mean±S.D., n=6), PCA motoneurons received 13±5 (n=6), and laryngeal constrictor (LCS) motoneurons received 11±4 (n=5). In contrast to our previous finding of a preferential serotonin innervation of CT motoneurons, we found no significant difference between the substance P inputs to CT, PCA and LCS motoneurons. Our results indicate a modest role for substance P in control of laryngeal motoneuronal function.
UR - http://www.scopus.com/inward/record.url?scp=0038642441&partnerID=8YFLogxK
U2 - 10.1016/S1569-9048(03)00136-8
DO - 10.1016/S1569-9048(03)00136-8
M3 - Article
C2 - 12871673
AN - SCOPUS:0038642441
VL - 137
SP - 11
EP - 18
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
IS - 1
ER -