Substance P inputs to laryngeal motoneurons in the rat

Qi Jian Sun, Robert G. Berkowitz, Ann K. Goodchild, Paul M. Pilowsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Substance P terminals have previously been demonstrated around retrogradely labelled posterior cricoarytenoid (PCA) motoneurons, but little is known regarding substance P inputs to other functionally identified laryngeal motoneurons. In the present study, we determined the number and distribution of close appositions between substance P immunoreactive boutons and three types of laryngeal motoneuron by using a combination of intracellular recording, dye-filling and immunocytochemistry in the rat. Cricothyroid (CT) motoneurons received 15±5 substance P appositions/neuron (mean±S.D., n=6), PCA motoneurons received 13±5 (n=6), and laryngeal constrictor (LCS) motoneurons received 11±4 (n=5). In contrast to our previous finding of a preferential serotonin innervation of CT motoneurons, we found no significant difference between the substance P inputs to CT, PCA and LCS motoneurons. Our results indicate a modest role for substance P in control of laryngeal motoneuronal function.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalRespiratory Physiology and Neurobiology
Volume137
Issue number1
DOIs
Publication statusPublished - 14 Aug 2003
Externally publishedYes

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