Successful treatment of oleander intoxication (cardiac glycosides) with digoxin-specific Fab antibody fragments in a 7-year-old child: Case report and review of literature

C. Camphausen; N. A. Haas; A. C. Mattke

doi:10.1007/s00392-005-0293-3

Successful treatment of oleander intoxication (cardiac glycosides) with digoxin-specific Fab antibody fragments in a 7-year-old child: Case report and review of literature

C. Camphausen^*, N. A. Haas, A. C. Mattke

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

28 Citations (Scopus)

Abstract

A 7-year-old girl presented six hours after ingestion of a yellow oleander seed (Thevetia peruviana) with severe emesis, change in colour vision and complete heart block. Initial treatment with phenytoin and isoprenalin infusion led to intermittent supraventricular and ventricular tachycardia. The patient was then treated with two intravenous doses of 190 mg of digoxin-specific Fab antibody fragments (Digibind®). Subsequently the patient's rhythm reverted to sinus rhythm and the symptoms resolved within 2 hours. Conclusion: administration of digoxin-specific Fab antibody fragments in an otherwise healthy child after oleander intoxication is safe and without adverse reactions.

Original language	English
Pages (from-to)	817-823
Number of pages	7
Journal	Zeitschrift fur Kardiologie
Volume	94
Issue number	12
DOIs	https://doi.org/10.1007/s00392-005-0293-3
Publication status	Published - Dec 2005
Externally published	Yes

Keywords

Cardiac glycosides
Child
Digoxin-specific Fab antibody fragments
Intoxication
Oleander

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10.1007/s00392-005-0293-3

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title = "Successful treatment of oleander intoxication (cardiac glycosides) with digoxin-specific Fab antibody fragments in a 7-year-old child: Case report and review of literature",

abstract = "A 7-year-old girl presented six hours after ingestion of a yellow oleander seed (Thevetia peruviana) with severe emesis, change in colour vision and complete heart block. Initial treatment with phenytoin and isoprenalin infusion led to intermittent supraventricular and ventricular tachycardia. The patient was then treated with two intravenous doses of 190 mg of digoxin-specific Fab antibody fragments (Digibind{\textregistered}). Subsequently the patient's rhythm reverted to sinus rhythm and the symptoms resolved within 2 hours. Conclusion: administration of digoxin-specific Fab antibody fragments in an otherwise healthy child after oleander intoxication is safe and without adverse reactions.",

keywords = "Cardiac glycosides, Child, Digoxin-specific Fab antibody fragments, Intoxication, Oleander",

author = "C. Camphausen and Haas, {N. A.} and Mattke, {A. C.}",

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T1 - Successful treatment of oleander intoxication (cardiac glycosides) with digoxin-specific Fab antibody fragments in a 7-year-old child

T2 - Case report and review of literature

AU - Camphausen, C.

AU - Haas, N. A.

AU - Mattke, A. C.

PY - 2005/12

Y1 - 2005/12

N2 - A 7-year-old girl presented six hours after ingestion of a yellow oleander seed (Thevetia peruviana) with severe emesis, change in colour vision and complete heart block. Initial treatment with phenytoin and isoprenalin infusion led to intermittent supraventricular and ventricular tachycardia. The patient was then treated with two intravenous doses of 190 mg of digoxin-specific Fab antibody fragments (Digibind®). Subsequently the patient's rhythm reverted to sinus rhythm and the symptoms resolved within 2 hours. Conclusion: administration of digoxin-specific Fab antibody fragments in an otherwise healthy child after oleander intoxication is safe and without adverse reactions.

AB - A 7-year-old girl presented six hours after ingestion of a yellow oleander seed (Thevetia peruviana) with severe emesis, change in colour vision and complete heart block. Initial treatment with phenytoin and isoprenalin infusion led to intermittent supraventricular and ventricular tachycardia. The patient was then treated with two intravenous doses of 190 mg of digoxin-specific Fab antibody fragments (Digibind®). Subsequently the patient's rhythm reverted to sinus rhythm and the symptoms resolved within 2 hours. Conclusion: administration of digoxin-specific Fab antibody fragments in an otherwise healthy child after oleander intoxication is safe and without adverse reactions.

KW - Cardiac glycosides

KW - Child

KW - Digoxin-specific Fab antibody fragments

KW - Intoxication

KW - Oleander

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JO - Zeitschrift fur Kardiologie

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Successful treatment of oleander intoxication (cardiac glycosides) with digoxin-specific Fab antibody fragments in a 7-year-old child: Case report and review of literature

Abstract

Keywords

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