Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis

Juliano Morimoto, Alistair Senior, Kate Ruiz, Jibran A. Wali, Tamara Pulpitel, Samantha M. Solon-Biet, Victoria C. Cogger, David Raubenheimer, David G. Le Couteur, Stephen J. Simpson, Joerg Eberhard*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
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Abstract

While there is a burgeoning interest in the effects of nutrition on systemic inflammatory diseases, how dietary macronutrient balance impacts local chronic inflammatory diseases in the mouth has been largely overlooked. Here, we used the Geometric Framework for Nutrition to test how the amounts of dietary macronutrients and their interactions, as well as carbohydrate type (starch vs sucrose vs resistant starch) influenced periodontitis-associated alveolar bone height in mice. Increasing intake of carbohydrates reduced alveolar bone height, while dietary protein had no effect. Whether carbohydrate came from sugar or starch did not influence the extent of alveolar bone height. In summary, the amount of carbohydrate in the diet modulated periodontitis-associated alveolar bone height independent of the source of carbohydrates.

Original languageEnglish
Article numbere0212796
Pages (from-to)1-10
Number of pages10
JournalPLoS ONE
Volume14
Issue number3
DOIs
Publication statusPublished - 13 Mar 2019

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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