Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis

Juliano Morimoto; Alistair Senior; Kate Ruiz; Jibran A. Wali; Tamara Pulpitel; Samantha M. Solon-Biet; Victoria C. Cogger; David Raubenheimer; David G. Le Couteur; Stephen J. Simpson; Joerg Eberhard

doi:10.1371/journal.pone.0212796

Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis

Juliano Morimoto, Alistair Senior, Kate Ruiz, Jibran A. Wali, Tamara Pulpitel, Samantha M. Solon-Biet, Victoria C. Cogger, David Raubenheimer, David G. Le Couteur, Stephen J. Simpson, Joerg Eberhard^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

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Abstract

While there is a burgeoning interest in the effects of nutrition on systemic inflammatory diseases, how dietary macronutrient balance impacts local chronic inflammatory diseases in the mouth has been largely overlooked. Here, we used the Geometric Framework for Nutrition to test how the amounts of dietary macronutrients and their interactions, as well as carbohydrate type (starch vs sucrose vs resistant starch) influenced periodontitis-associated alveolar bone height in mice. Increasing intake of carbohydrates reduced alveolar bone height, while dietary protein had no effect. Whether carbohydrate came from sugar or starch did not influence the extent of alveolar bone height. In summary, the amount of carbohydrate in the diet modulated periodontitis-associated alveolar bone height independent of the source of carbohydrates.

Original language	English
Article number	e0212796
Pages (from-to)	1-10
Number of pages	10
Journal	PLoS ONE
Volume	14
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0212796
Publication status	Published - 13 Mar 2019

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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10.1371/journal.pone.0212796Licence: CC BY

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Morimoto, J., Senior, A., Ruiz, K., Wali, J. A., Pulpitel, T., Solon-Biet, S. M., Cogger, V. C., Raubenheimer, D., Le Couteur, D. G., Simpson, S. J., & Eberhard, J. (2019). Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis. PLoS ONE, 14(3), 1-10. [e0212796]. https://doi.org/10.1371/journal.pone.0212796

Morimoto, Juliano ; Senior, Alistair ; Ruiz, Kate ; Wali, Jibran A. ; Pulpitel, Tamara ; Solon-Biet, Samantha M. ; Cogger, Victoria C. ; Raubenheimer, David ; Le Couteur, David G. ; Simpson, Stephen J. ; Eberhard, Joerg. / Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis. In: PLoS ONE. 2019 ; Vol. 14, No. 3. pp. 1-10.

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title = "Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis",

abstract = "While there is a burgeoning interest in the effects of nutrition on systemic inflammatory diseases, how dietary macronutrient balance impacts local chronic inflammatory diseases in the mouth has been largely overlooked. Here, we used the Geometric Framework for Nutrition to test how the amounts of dietary macronutrients and their interactions, as well as carbohydrate type (starch vs sucrose vs resistant starch) influenced periodontitis-associated alveolar bone height in mice. Increasing intake of carbohydrates reduced alveolar bone height, while dietary protein had no effect. Whether carbohydrate came from sugar or starch did not influence the extent of alveolar bone height. In summary, the amount of carbohydrate in the diet modulated periodontitis-associated alveolar bone height independent of the source of carbohydrates.",

author = "Juliano Morimoto and Alistair Senior and Kate Ruiz and Wali, {Jibran A.} and Tamara Pulpitel and Solon-Biet, {Samantha M.} and Cogger, {Victoria C.} and David Raubenheimer and {Le Couteur}, {David G.} and Simpson, {Stephen J.} and Joerg Eberhard",

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Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis. / Morimoto, Juliano; Senior, Alistair; Ruiz, Kate; Wali, Jibran A.; Pulpitel, Tamara; Solon-Biet, Samantha M.; Cogger, Victoria C.; Raubenheimer, David; Le Couteur, David G.; Simpson, Stephen J.; Eberhard, Joerg.

In: PLoS ONE, Vol. 14, No. 3, e0212796, 13.03.2019, p. 1-10.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis

AU - Morimoto, Juliano

AU - Senior, Alistair

AU - Ruiz, Kate

AU - Wali, Jibran A.

AU - Pulpitel, Tamara

AU - Solon-Biet, Samantha M.

AU - Cogger, Victoria C.

AU - Raubenheimer, David

AU - Le Couteur, David G.

AU - Simpson, Stephen J.

AU - Eberhard, Joerg

N1 - Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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Y1 - 2019/3/13

N2 - While there is a burgeoning interest in the effects of nutrition on systemic inflammatory diseases, how dietary macronutrient balance impacts local chronic inflammatory diseases in the mouth has been largely overlooked. Here, we used the Geometric Framework for Nutrition to test how the amounts of dietary macronutrients and their interactions, as well as carbohydrate type (starch vs sucrose vs resistant starch) influenced periodontitis-associated alveolar bone height in mice. Increasing intake of carbohydrates reduced alveolar bone height, while dietary protein had no effect. Whether carbohydrate came from sugar or starch did not influence the extent of alveolar bone height. In summary, the amount of carbohydrate in the diet modulated periodontitis-associated alveolar bone height independent of the source of carbohydrates.

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Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis

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