Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3

Heather J. Lacey; Rachel Chen; Daniel Vuong; Mark F. Fisher; Ernest Lacey; Peter J. Rutledge; Andrew M. Piggott

doi:10.1038/s41429-022-00544-4

Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3

Heather J. Lacey^*, Rachel Chen, Daniel Vuong, Mark F. Fisher, Ernest Lacey, Peter J. Rutledge, Andrew M. Piggott

^*Corresponding author for this work

School of Natural Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Amycolatopsis sp. MST-135876 was isolated from soil collected from the riverbank of El Pont de Suert, Catalonia, Spain. Cultivation of MST-135876 on a range of media led to the discovery of a previously unreported dichlorinated cyclic hexapeptide, suertide A (D-Ser, 5-Cl-D-Trp, 6-Cl-D-Trp, L-Ile, D-Val, D-Glu), featuring an unprecedented pair of adjacent 5/6-chlorotryptophan residues. Supplementing the growth medium with KBr resulted in production of the mono- and dibrominated analogues suertides B and C, respectively. Suertides A–C displayed selective activity against Bacillus subtilis (MIC 1.6 µg ml⁻¹) and Staphylococcus aureus (MIC 3.1, 6.3, and 12.5 µg ml⁻¹, respectively), while suertides A and B showed appreciable activity against methicillin-resistant S. aureus (MIC 1.6 and 6.3 µg ml⁻¹, respectively).

Original language	English
Pages (from-to)	483-490
Number of pages	8
Journal	Journal of Antibiotics
Volume	75
Issue number	9
Early online date	26 Jul 2022
DOIs	https://doi.org/10.1038/s41429-022-00544-4
Publication status	Published - Sept 2022

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Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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@article{28cbf2cf76664a55af8ad64883f29ca1,

title = "Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3",

abstract = "Amycolatopsis sp. MST-135876 was isolated from soil collected from the riverbank of El Pont de Suert, Catalonia, Spain. Cultivation of MST-135876 on a range of media led to the discovery of a previously unreported dichlorinated cyclic hexapeptide, suertide A (D-Ser, 5-Cl-D-Trp, 6-Cl-D-Trp, L-Ile, D-Val, D-Glu), featuring an unprecedented pair of adjacent 5/6-chlorotryptophan residues. Supplementing the growth medium with KBr resulted in production of the mono- and dibrominated analogues suertides B and C, respectively. Suertides A–C displayed selective activity against Bacillus subtilis (MIC 1.6 µg ml−1) and Staphylococcus aureus (MIC 3.1, 6.3, and 12.5 µg ml−1, respectively), while suertides A and B showed appreciable activity against methicillin-resistant S. aureus (MIC 1.6 and 6.3 µg ml−1, respectively).",

author = "Lacey, {Heather J.} and Rachel Chen and Daniel Vuong and Fisher, {Mark F.} and Ernest Lacey and Rutledge, {Peter J.} and Piggott, {Andrew M.}",

note = "Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher. ",

year = "2022",

month = sep,

doi = "10.1038/s41429-022-00544-4",

language = "English",

volume = "75",

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T2 - selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3

AU - Lacey, Heather J.

AU - Chen, Rachel

AU - Vuong, Daniel

AU - Fisher, Mark F.

AU - Lacey, Ernest

AU - Rutledge, Peter J.

AU - Piggott, Andrew M.

N1 - Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2022/9

Y1 - 2022/9

N2 - Amycolatopsis sp. MST-135876 was isolated from soil collected from the riverbank of El Pont de Suert, Catalonia, Spain. Cultivation of MST-135876 on a range of media led to the discovery of a previously unreported dichlorinated cyclic hexapeptide, suertide A (D-Ser, 5-Cl-D-Trp, 6-Cl-D-Trp, L-Ile, D-Val, D-Glu), featuring an unprecedented pair of adjacent 5/6-chlorotryptophan residues. Supplementing the growth medium with KBr resulted in production of the mono- and dibrominated analogues suertides B and C, respectively. Suertides A–C displayed selective activity against Bacillus subtilis (MIC 1.6 µg ml−1) and Staphylococcus aureus (MIC 3.1, 6.3, and 12.5 µg ml−1, respectively), while suertides A and B showed appreciable activity against methicillin-resistant S. aureus (MIC 1.6 and 6.3 µg ml−1, respectively).

AB - Amycolatopsis sp. MST-135876 was isolated from soil collected from the riverbank of El Pont de Suert, Catalonia, Spain. Cultivation of MST-135876 on a range of media led to the discovery of a previously unreported dichlorinated cyclic hexapeptide, suertide A (D-Ser, 5-Cl-D-Trp, 6-Cl-D-Trp, L-Ile, D-Val, D-Glu), featuring an unprecedented pair of adjacent 5/6-chlorotryptophan residues. Supplementing the growth medium with KBr resulted in production of the mono- and dibrominated analogues suertides B and C, respectively. Suertides A–C displayed selective activity against Bacillus subtilis (MIC 1.6 µg ml−1) and Staphylococcus aureus (MIC 3.1, 6.3, and 12.5 µg ml−1, respectively), while suertides A and B showed appreciable activity against methicillin-resistant S. aureus (MIC 1.6 and 6.3 µg ml−1, respectively).

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DO - 10.1038/s41429-022-00544-4

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AN - SCOPUS:85135002005

SN - 0021-8820

VL - 75

SP - 483

EP - 490

JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 9

ER -

Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3

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Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3

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