[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation

W. Richard Bevan Jones, Thomas E. Cope, Luca Passamonti, Tim D. Fryer, Young T. Hong, Franklin Aigbirhio, Jillian J. Kril, Shelley L. Forrest, Kieren Allinson, Jonathan P. Coles, P. Simon Jones, Maria G. Spillantini, John R. Hodges, John T. O'Brien, James B. Rowe

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Abstract

The validation of tau radioligands could improve the diagnosis of frontotemporal lobar degeneration and the assessment of disease-modifying therapies. Here, we demonstrate that binding of the tau radioligand [18F]AV-1451 was significantly abnormal in both magnitude and distribution in a patient with familial frontotemporal dementia due to a MAPT 10 + 16C>T gene mutation, recapitulating the pattern of neuropathology seen in her father. Given the genetic diagnosis and the non-Alzheimer's pathology, these findings suggest that [18F]AV-1451 might be a useful biomarker in primary tauopathies. Largerscale in vivo and post-mortem studies will be needed to assess the technique's specificity.

Original languageEnglish
Pages (from-to)940-947
Number of pages8
JournalAnnals of Clinical and Translational Neurology
Volume3
Issue number12
DOIs
Publication statusPublished - Dec 2016
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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