Surface energy changes and their relationship with the dispersibility of salmeterol xinafoate powders for inhalation after storage at high RH

Shyamal Das, Ian Larson, Paul Young, Peter Stewart

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

This study investigated the relationship between surface energy of micronized lactose, coarse lactose and salmeterol xinafoate and dispersibility from a mixture after storage at 75% RH. Surface energies, dispersibility, morphology, and the presence of amorphous domains were determined by inverse gas chromatography, twin stage impinger, scanning electron microscope and dynamic vapour sorption, respectively. The fine particle fraction of mixture decreased significantly in 4 weeks (P < 0.05), reaching a static level in 3 months. Amorphous content was not detected in the micronized lactose, coarse lactose and salmeterol xinafoate. After conditioning stored samples at 75% RH for 2 h, dispersive surface energy of both micronized and coarse lactose significantly decreased (P < 0.05), while the polar surface energy of all significantly increased (P < 0.05) resulting in significant increase in total surface energy after storage. After conditioning stored samples at 0% RH for 2 h, no significant difference was observed in any surface energy parameter. This study concluded that the total surface energy increased during storage at high RH due to the adhered surface moisture. The mechanism of decreased dispersibility was related to increased capillary/solid bridging interactions and to possible increased interaction of contiguous particles due to increased polar surface energy.
Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalEuropean Journal of Pharmaceutical Sciences
Volume38
Issue number4
DOIs
Publication statusPublished - 5 Nov 2009
Externally publishedYes

Keywords

  • Surface energy
  • Dispersibility
  • Storage
  • Relative humidity
  • Salmeterol xinafoate
  • Powder for inhalation

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