Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology

Yuling Wang; Joseph Irudayaraj

doi:10.1098/rstb.2012.0026

Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology

Yuling Wang, Joseph Irudayaraj^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article

51 Citations (Scopus)

Abstract

Single-molecule (SM) spectroscopy has been an exciting area of research offering significant promise and hope in the field of sensor development to detect targets at ultra-low levels down to SM resolution. To the experts and developers in the field of surface-enhanced Raman spectroscopy (SERS), this has often been a challenge and a significant opportunity for exploration. Needless to say, the opportunities and excitement of this multidisciplinary area impacts span the fields of physics, chemistry and engineering, along with a significant thrust in applications constituting areas in medicine, biology, environment and agriculture among others. In this review, we will attempt to provide a quick snapshot of the basics of SM-SERS, nanostructures and devices that can enable SM Raman measurement. We will conclude with a discussion on SERS implications in biomedical sciences.

Original language	English
Article number	20120026
Pages (from-to)	1-10
Number of pages	10
Journal	Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume	368
Issue number	1611
DOIs	https://doi.org/10.1098/rstb.2012.0026
Publication status	Published - 5 Feb 2013
Externally published	Yes

Keywords

single molecule
surface-enhanced Raman spectroscopy
nanotechnology
hot spot
biological sciences

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