TY - JOUR
T1 - Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology
AU - Wang, Yuling
AU - Irudayaraj, Joseph
PY - 2013/2/5
Y1 - 2013/2/5
N2 - Single-molecule (SM) spectroscopy has been an exciting area of research offering significant promise and hope in the field of sensor development to detect targets at ultra-low levels down to SM resolution. To the experts and developers in the field of surface-enhanced Raman spectroscopy (SERS), this has often been a challenge and a significant opportunity for exploration. Needless to say, the opportunities and excitement of this multidisciplinary area impacts span the fields of physics, chemistry and engineering, along with a significant thrust in applications constituting areas in medicine, biology, environment and agriculture among others. In this review, we will attempt to provide a quick snapshot of the basics of SM-SERS, nanostructures and devices that can enable SM Raman measurement. We will conclude with a discussion on SERS implications in biomedical sciences.
AB - Single-molecule (SM) spectroscopy has been an exciting area of research offering significant promise and hope in the field of sensor development to detect targets at ultra-low levels down to SM resolution. To the experts and developers in the field of surface-enhanced Raman spectroscopy (SERS), this has often been a challenge and a significant opportunity for exploration. Needless to say, the opportunities and excitement of this multidisciplinary area impacts span the fields of physics, chemistry and engineering, along with a significant thrust in applications constituting areas in medicine, biology, environment and agriculture among others. In this review, we will attempt to provide a quick snapshot of the basics of SM-SERS, nanostructures and devices that can enable SM Raman measurement. We will conclude with a discussion on SERS implications in biomedical sciences.
KW - single molecule
KW - surface-enhanced Raman spectroscopy
KW - nanotechnology
KW - hot spot
KW - biological sciences
UR - http://www.scopus.com/inward/record.url?scp=84878756962&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/record.url?scp=84871675581&partnerID=8YFLogxK
U2 - 10.1098/rstb.2012.0026
DO - 10.1098/rstb.2012.0026
M3 - Review article
C2 - 23267180
AN - SCOPUS:84871675581
SN - 0962-8436
VL - 368
SP - 1
EP - 10
JO - Philosophical transactions of the Royal Society of London. Series B, Biological sciences
JF - Philosophical transactions of the Royal Society of London. Series B, Biological sciences
IS - 1611
M1 - 20120026
ER -