Surgical biopsy with intra-operative frozen section

Robert U. Ashford*, S. W. McCarthy, R. A. Scolyer, S. F. Bonar, R. Z. Karim, P. D. Stalley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

The most appropriate protocol for the biopsy of musculoskeletal tumours is controversial, with some authors advocating CT-guided core biopsy. At our hospital the initial biopsies of most musculoskeletal tumours has been by operative core biopsy with evaluation by frozen section which determines whether diagnostic tissue has been obtained and, if possible, gives the definitive diagnosis. In order to determine the accuracy and cost-effectiveness of this protocol we have undertaken a retrospective audit of biopsies of musculoskeletal tumours performed over a period of two years. A total of 104 patients had biopsies according to this regime. All gave the diagnosis apart from one minor error which did not alter the management of the patient. There was no requirement for re-biopsy. This protocol was more labour-intensive and 38% more costly than CT-guided core biopsy (AU$1804 vs AU$1308). However, the accuracy and avoidance of the anxiety associated with repeat biopsy outweighed these disadvantages.

Original languageEnglish
Pages (from-to)1207-1211
Number of pages5
JournalJournal of Bone and Joint Surgery - Series B
Volume88
Issue number9
DOIs
Publication statusPublished - Sep 2006
Externally publishedYes

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