Survival after diagnosis of hepatocellular carcinoma and potential impact of treatment in a hepatitis B or C infected cohort

Hla-Hla Thein; Scott R. Walter; Heather F. Gidding; Janaki Amin; Matthew G. Law; Jacob George; Gregory J. Dore

doi:10.1111/j.1872-034X.2012.01037.x

Survival after diagnosis of hepatocellular carcinoma and potential impact of treatment in a hepatitis B or C infected cohort

Hla-Hla Thein^*, Scott R. Walter, Heather F. Gidding, Janaki Amin, Matthew G. Law, Jacob George, Gregory J. Dore

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Aim: Little is known about the patterns of care and the impact of hepatocellular carcinoma (HCC) treatment on health outcomes at a population level. We conducted a population-based cohort study to examine HCC survival trends among people diagnosed with hepatitis B (HBV) or hepatitis C virus (HCV) infection, to determine predictors of receiving potentially curative therapy for HCC, and to examine the impact of HCC treatment on survival in New South Wales, Australia.

Methods: The KaplanMeier method was used to estimate survival, logistic regression to determine predictors of potentially curative therapy and Cox proportional hazards models to determine the impact of HCC treatment on survival. Years of potential life lost (YPLL) were calculated.

Results: During the period 19932007, 1081 cases of HCC were diagnosed. Median survival increased from 10.4 months during 19931997 to 18.4 months during 19982002, with no further improvement thereafter. Younger age at diagnosis (

Conclusion: The burden of viral hepatitis-related HCC is substantial. Despite treatment advances in recent years, there has been no significant improvement in HCC survival. Efforts to improve HCC screening and early diagnosis are required to deliver curative treatment which clearly has a survival advantage.

Original language	English
Pages (from-to)	1175-1186
Number of pages	12
Journal	Hepatology Research
Volume	42
Issue number	12
DOIs	https://doi.org/10.1111/j.1872-034X.2012.01037.x
Publication status	Published - Dec 2012
Externally published	Yes

Keywords

Australia
hepatitis B virus
hepatitis C virus
hepatocellular carcinoma
survival
treatment outcome

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10.1111/j.1872-034X.2012.01037.x

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title = "Survival after diagnosis of hepatocellular carcinoma and potential impact of treatment in a hepatitis B or C infected cohort",

abstract = "Aim: Little is known about the patterns of care and the impact of hepatocellular carcinoma (HCC) treatment on health outcomes at a population level. We conducted a population-based cohort study to examine HCC survival trends among people diagnosed with hepatitis B (HBV) or hepatitis C virus (HCV) infection, to determine predictors of receiving potentially curative therapy for HCC, and to examine the impact of HCC treatment on survival in New South Wales, Australia.Methods: The KaplanMeier method was used to estimate survival, logistic regression to determine predictors of potentially curative therapy and Cox proportional hazards models to determine the impact of HCC treatment on survival. Years of potential life lost (YPLL) were calculated.Results: During the period 19932007, 1081 cases of HCC were diagnosed. Median survival increased from 10.4 months during 19931997 to 18.4 months during 19982002, with no further improvement thereafter. Younger age at diagnosis (Conclusion: The burden of viral hepatitis-related HCC is substantial. Despite treatment advances in recent years, there has been no significant improvement in HCC survival. Efforts to improve HCC screening and early diagnosis are required to deliver curative treatment which clearly has a survival advantage.",

keywords = "Australia, hepatitis B virus, hepatitis C virus, hepatocellular carcinoma, survival, treatment outcome",

author = "Hla-Hla Thein and Walter, {Scott R.} and Gidding, {Heather F.} and Janaki Amin and Law, {Matthew G.} and Jacob George and Dore, {Gregory J.}",

year = "2012",

month = dec,

doi = "10.1111/j.1872-034X.2012.01037.x",

language = "English",

volume = "42",

pages = "1175--1186",

journal = "Hepatology Research",

issn = "1386-6346",

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}

Survival after diagnosis of hepatocellular carcinoma and potential impact of treatment in a hepatitis B or C infected cohort. / Thein, Hla-Hla; Walter, Scott R.; Gidding, Heather F.; Amin, Janaki; Law, Matthew G.; George, Jacob; Dore, Gregory J.

In: Hepatology Research, Vol. 42, No. 12, 12.2012, p. 1175-1186.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Survival after diagnosis of hepatocellular carcinoma and potential impact of treatment in a hepatitis B or C infected cohort

AU - Thein, Hla-Hla

AU - Walter, Scott R.

AU - Gidding, Heather F.

AU - Amin, Janaki

AU - Law, Matthew G.

AU - George, Jacob

AU - Dore, Gregory J.

PY - 2012/12

Y1 - 2012/12

N2 - Aim: Little is known about the patterns of care and the impact of hepatocellular carcinoma (HCC) treatment on health outcomes at a population level. We conducted a population-based cohort study to examine HCC survival trends among people diagnosed with hepatitis B (HBV) or hepatitis C virus (HCV) infection, to determine predictors of receiving potentially curative therapy for HCC, and to examine the impact of HCC treatment on survival in New South Wales, Australia.Methods: The KaplanMeier method was used to estimate survival, logistic regression to determine predictors of potentially curative therapy and Cox proportional hazards models to determine the impact of HCC treatment on survival. Years of potential life lost (YPLL) were calculated.Results: During the period 19932007, 1081 cases of HCC were diagnosed. Median survival increased from 10.4 months during 19931997 to 18.4 months during 19982002, with no further improvement thereafter. Younger age at diagnosis (Conclusion: The burden of viral hepatitis-related HCC is substantial. Despite treatment advances in recent years, there has been no significant improvement in HCC survival. Efforts to improve HCC screening and early diagnosis are required to deliver curative treatment which clearly has a survival advantage.

AB - Aim: Little is known about the patterns of care and the impact of hepatocellular carcinoma (HCC) treatment on health outcomes at a population level. We conducted a population-based cohort study to examine HCC survival trends among people diagnosed with hepatitis B (HBV) or hepatitis C virus (HCV) infection, to determine predictors of receiving potentially curative therapy for HCC, and to examine the impact of HCC treatment on survival in New South Wales, Australia.Methods: The KaplanMeier method was used to estimate survival, logistic regression to determine predictors of potentially curative therapy and Cox proportional hazards models to determine the impact of HCC treatment on survival. Years of potential life lost (YPLL) were calculated.Results: During the period 19932007, 1081 cases of HCC were diagnosed. Median survival increased from 10.4 months during 19931997 to 18.4 months during 19982002, with no further improvement thereafter. Younger age at diagnosis (Conclusion: The burden of viral hepatitis-related HCC is substantial. Despite treatment advances in recent years, there has been no significant improvement in HCC survival. Efforts to improve HCC screening and early diagnosis are required to deliver curative treatment which clearly has a survival advantage.

KW - Australia

KW - hepatitis B virus

KW - hepatitis C virus

KW - hepatocellular carcinoma

KW - survival

KW - treatment outcome

U2 - 10.1111/j.1872-034X.2012.01037.x

DO - 10.1111/j.1872-034X.2012.01037.x

M3 - Article

C2 - 22607544

VL - 42

SP - 1175

EP - 1186

JO - Hepatology Research

JF - Hepatology Research

SN - 1386-6346

IS - 12

ER -

Survival after diagnosis of hepatocellular carcinoma and potential impact of treatment in a hepatitis B or C infected cohort

Abstract

Keywords

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