Survival outcomes for stage-matched endoscopic and open resection of olfactory neuroblastoma

Richard J. Harvey*, Sunny Nalavenkata, Raymond Sacks, Nithin D. Adappa, James N. Palmer, Michael T. Purkey, Rodney J. Schlosser, Carl Snyderman, Eric W. Wang, Bradford A. Woodworth, Robert Smee, Tom Havas, Richard Gallagher

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Background: Advanced-stage olfactory neuroblastoma requires multimodal therapy for optimal outcomes. Debate exists over endoscopic endonasal surgery in this situation. Stage-matched open and endoscopic surgical therapy were compared. Methods: Patients from 6 cancer institutions were assessed. Stratification included dural involvement, Kadish stage, nodal disease, Hyams' grade, approach, and margin status. At follow-up, local control, nodal status, and evidence of distant metastases were recorded with any subsequent therapy. Statistical analyses to identify risk factors for developing recurrence and survival differences were performed. Results: One hundred nine patients were assessed (age 49.2 ± 13.0 years; 46% women) representing Kadish A stage (10%), Kadish B stage (25%), and Kadish C stage (65%). The majority of the patients (61.5%) underwent endoscopic resection, 53.5% within Kadish C stage. Within-stage survival analysis favored endoscopic subgroup for Kadish C stage (log-rank P = .017) nonsignificant for Kadish B stage (log-rank P = .39). Conclusion: Stage-matched survival was better for the endoscopically treated group compared to the open surgery group, with high negative margin resections obtained.

Original languageEnglish
Pages (from-to)2425-2432
Number of pages8
JournalHead and Neck
Issue number12
Early online date25 Sep 2017
Publication statusPublished - Dec 2017


  • Endoscopy
  • Esthesioneuroblastoma
  • Metastases
  • Outcomes
  • Radiotherapy
  • Surgery
  • Survival

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