TY - JOUR
T1 - Sustained release from mesoporous nanoparticles
T2 - Evaluation of structural properties associated with release rate
AU - Brohede, Ulrika
AU - Atluri, Rambabu
AU - Garcia-Bennett, Alfonso E.
AU - Strømme, Maria
PY - 2008/7
Y1 - 2008/7
N2 - We present here a detailed study of the controlled release of amino acid derived amphiphilic molecules from the internal pore structure of mesoporous nanoparticle drug delivery systems with different structural properties; namely cubic and hexagonal structures of various degrees of complexity. The internal pore surface of the nanomaterials presented has been functionalised with amine moieties through a one pot method. Release profiles obtained by Alternating Ionic Current measurements are interpreted in terms of specific structural and textural parameters of the porous nanoparticles such as pore geometry and connectivity. Results indicate that diffusion coefficients are lower by as much as four orders of magnitude in 2-dimensional structures in comparison to 3-dimensional mesoporous solids. A fast release in turn is observed from mesocaged materials AMS-9 and AMS-8 where the presence of structural defects is thought to lead to a slightly lower diffusion coefficient in the latter. Amount of pore wall functionalisation and number of binding sites on the model drug are found to have little effect on the drug release rate.
AB - We present here a detailed study of the controlled release of amino acid derived amphiphilic molecules from the internal pore structure of mesoporous nanoparticle drug delivery systems with different structural properties; namely cubic and hexagonal structures of various degrees of complexity. The internal pore surface of the nanomaterials presented has been functionalised with amine moieties through a one pot method. Release profiles obtained by Alternating Ionic Current measurements are interpreted in terms of specific structural and textural parameters of the porous nanoparticles such as pore geometry and connectivity. Results indicate that diffusion coefficients are lower by as much as four orders of magnitude in 2-dimensional structures in comparison to 3-dimensional mesoporous solids. A fast release in turn is observed from mesocaged materials AMS-9 and AMS-8 where the presence of structural defects is thought to lead to a slightly lower diffusion coefficient in the latter. Amount of pore wall functionalisation and number of binding sites on the model drug are found to have little effect on the drug release rate.
KW - Alternating ionic current measurements
KW - Controlled drag release
KW - Mesoporous nanoparticles
KW - TEM
UR - http://www.scopus.com/inward/record.url?scp=47149090056&partnerID=8YFLogxK
U2 - 10.2174/156720108784911686
DO - 10.2174/156720108784911686
M3 - Article
C2 - 18673261
AN - SCOPUS:47149090056
SN - 1567-2018
VL - 5
SP - 177
EP - 185
JO - Current Drug Delivery
JF - Current Drug Delivery
IS - 3
ER -