svReg: structural varying-coefficient regression to differentiate how regional brain atrophy affects motor impairment for Huntington disease severity groups

Rakheon Kim*, Samuel Müller, Tanya P. Garcia

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    For Huntington disease, identification of brain regions related to motor impairment can be useful for developing interventions to alleviate the motor symptom, the major symptom of the disease. However, the effects from the brain regions to motor impairment may vary for different groups of patients. Hence, our interest is not only to identify the brain regions but also to understand how their effects on motor impairment differ by patient groups. This can be cast as a model selection problem for a varying-coefficient regression. However, this is challenging when there is a pre-specified group structure among variables. We propose a novel variable selection method for a varying-coefficient regression with such structured variables and provide a publicly available R package svreg for implementation of our method. Our method is empirically shown to select relevant variables consistently. Also, our method screens irrelevant variables better than existing methods. Hence, our method leads to a model with higher sensitivity, lower false discovery rate and higher prediction accuracy than the existing methods. Finally, we found that the effects from the brain regions to motor impairment differ by disease severity of the patients. To the best of our knowledge, our study is the first to identify such interaction effects between the disease severity and brain regions, which indicates the need for customized intervention by disease severity.

    Original languageEnglish
    Pages (from-to)1254-1271
    Number of pages18
    JournalBiometrical Journal
    Volume63
    Issue number6
    DOIs
    Publication statusPublished - Aug 2021

    Keywords

    • Huntington disease
    • interaction model
    • pliable Lasso
    • structural varying-coefficient regression
    • variable selection

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