Sydowiols A-C

Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii

Xinru Liu, Fuhang Song, Li Ma, Caixia Chen, Xue Xiao, Biao Ren, Xueting Liu, Huanqin Dai, Andrew M. Piggott, Yossef Av-Gay, Lixin Zhang*, Robert J. Capon

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Chemical analysis of an East China Sea marine-derived fungus, Aspergillus sydowii (MF357) returned three new tris-pyrogallol ethers, sydowiols A-C (1-3), and two known bis-pyrogallol ethers, violaceols I (4) and II (5). Structures were assigned on the basis of detailed spectroscopic analysis and by consideration of symmetry. Sydowiols A (1) and C (3) were responsible for the inhibitory activity detected in the crude fungal extract against Mycobacterium tuberculosis protein tyrosine phosphatase A (PtpA).

Original languageEnglish
Pages (from-to)6081-6083
Number of pages3
JournalTetrahedron Letters
Volume54
Issue number45
DOIs
Publication statusPublished - 6 Nov 2013
Externally publishedYes

Keywords

  • Aspergillus sydowii
  • marine-derived fungus
  • Mycobacterium tuberculosis
  • protein tyrosine phosphatase A (PtpA)

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