Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii

Xinru Liu; Fuhang Song; Li Ma; Caixia Chen; Xue Xiao; Biao Ren; Xueting Liu; Huanqin Dai; Andrew M. Piggott; Yossef Av-Gay; Lixin Zhang; Robert J. Capon

doi:10.1016/j.tetlet.2013.08.137

Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii

Xinru Liu, Fuhang Song, Li Ma, Caixia Chen, Xue Xiao, Biao Ren, Xueting Liu, Huanqin Dai, Andrew M. Piggott, Yossef Av-Gay, Lixin Zhang^*, Robert J. Capon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Chemical analysis of an East China Sea marine-derived fungus, Aspergillus sydowii (MF357) returned three new tris-pyrogallol ethers, sydowiols A-C (1-3), and two known bis-pyrogallol ethers, violaceols I (4) and II (5). Structures were assigned on the basis of detailed spectroscopic analysis and by consideration of symmetry. Sydowiols A (1) and C (3) were responsible for the inhibitory activity detected in the crude fungal extract against Mycobacterium tuberculosis protein tyrosine phosphatase A (PtpA).

Original language	English
Pages (from-to)	6081-6083
Number of pages	3
Journal	Tetrahedron Letters
Volume	54
Issue number	45
DOIs	https://doi.org/10.1016/j.tetlet.2013.08.137
Publication status	Published - 6 Nov 2013
Externally published	Yes

Keywords

Aspergillus sydowii
marine-derived fungus
Mycobacterium tuberculosis
protein tyrosine phosphatase A (PtpA)

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10.1016/j.tetlet.2013.08.137

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title = "Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii",

abstract = "Chemical analysis of an East China Sea marine-derived fungus, Aspergillus sydowii (MF357) returned three new tris-pyrogallol ethers, sydowiols A-C (1-3), and two known bis-pyrogallol ethers, violaceols I (4) and II (5). Structures were assigned on the basis of detailed spectroscopic analysis and by consideration of symmetry. Sydowiols A (1) and C (3) were responsible for the inhibitory activity detected in the crude fungal extract against Mycobacterium tuberculosis protein tyrosine phosphatase A (PtpA).",

keywords = "Aspergillus sydowii, marine-derived fungus, Mycobacterium tuberculosis, protein tyrosine phosphatase A (PtpA)",

author = "Xinru Liu and Fuhang Song and Li Ma and Caixia Chen and Xue Xiao and Biao Ren and Xueting Liu and Huanqin Dai and Piggott, \{Andrew M.\} and Yossef Av-Gay and Lixin Zhang and Capon, \{Robert J.\}",

year = "2013",

month = nov,

day = "6",

doi = "10.1016/j.tetlet.2013.08.137",

language = "English",

volume = "54",

pages = "6081--6083",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Sydowiols A-C

T2 - Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii

AU - Liu, Xinru

AU - Song, Fuhang

AU - Ma, Li

AU - Chen, Caixia

AU - Xiao, Xue

AU - Ren, Biao

AU - Liu, Xueting

AU - Dai, Huanqin

AU - Piggott, Andrew M.

AU - Av-Gay, Yossef

AU - Zhang, Lixin

AU - Capon, Robert J.

PY - 2013/11/6

Y1 - 2013/11/6

N2 - Chemical analysis of an East China Sea marine-derived fungus, Aspergillus sydowii (MF357) returned three new tris-pyrogallol ethers, sydowiols A-C (1-3), and two known bis-pyrogallol ethers, violaceols I (4) and II (5). Structures were assigned on the basis of detailed spectroscopic analysis and by consideration of symmetry. Sydowiols A (1) and C (3) were responsible for the inhibitory activity detected in the crude fungal extract against Mycobacterium tuberculosis protein tyrosine phosphatase A (PtpA).

AB - Chemical analysis of an East China Sea marine-derived fungus, Aspergillus sydowii (MF357) returned three new tris-pyrogallol ethers, sydowiols A-C (1-3), and two known bis-pyrogallol ethers, violaceols I (4) and II (5). Structures were assigned on the basis of detailed spectroscopic analysis and by consideration of symmetry. Sydowiols A (1) and C (3) were responsible for the inhibitory activity detected in the crude fungal extract against Mycobacterium tuberculosis protein tyrosine phosphatase A (PtpA).

KW - Aspergillus sydowii

KW - marine-derived fungus

KW - Mycobacterium tuberculosis

KW - protein tyrosine phosphatase A (PtpA)

UR - https://www.scopus.com/pages/publications/84885319931

U2 - 10.1016/j.tetlet.2013.08.137

DO - 10.1016/j.tetlet.2013.08.137

M3 - Article

AN - SCOPUS:84885319931

SN - 0040-4039

VL - 54

SP - 6081

EP - 6083

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 45

ER -

Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii

Abstract

Keywords

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