Sympathetic preganglionic neurons projecting to the adrenal medulla and aorticorenal ganglion in the rabbit

Iwona Jensen, Paul Pilowsky*, Ida Llewellyn-Smith, Jane Minson, John Chalmers

*Corresponding author for this work

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    The distribution of sympathetic preganglionic neurons (SPN) projecting to the adrenal medulla and the aorticorenal ganglion in the rabbit was studied using a dual retrograde transport technique. The B subunit of cholera toxin (CTB) was injected into the left adrenal medulla and wheatgerm agglutinin-apo-horseradish peroxidase-7 nm gold (WGA-apo-HRP-gold) was injected into the left aorticorenal ganglion. Retrogradely transported CTB was detected by immunohistochemistry, while gold particels were detected by silver intensification. SPN projecting to the adrenal medulla were observed in segments T2-L2 of the spinal cord in 5 rabbits, with the majority of cells within segments T6-T11 (79%). SPN projecting to the aorticorenal ganglion were seen in segments T2-L1 of the spinal cord in 5 rabbits, with the greatest number of the cells within T6-T11 (81%). Only a small number of doubly labelled cells (1%) were found in two rabbits. The results suggest that despite their similar segmental distribution SPN projecting to the adrenal medulla or the aorticorenal ganglion belong to separate populations and few, if any, individual SPN have axonal projections to both locations.

    Original languageEnglish
    Pages (from-to)125-129
    Number of pages5
    JournalBrain Research
    Volume586
    Issue number1
    DOIs
    Publication statusPublished - 17 Jul 1992

    Keywords

    • Blood pressure
    • Cholera toxin B
    • Retrograde tracing
    • Spinal cord
    • Wheatgerm agglutinin-apo-horseradish peroxidase-gold

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