TY - JOUR
T1 - Symptoms of anxiety and depression are independently associated with inflammatory bowel disease-related disability
AU - Chan, Webber
AU - Shim, Hang Hock
AU - Lim, Miao Shan
AU - Sawadjaan, Fatimin Leila Bahjin
AU - Isaac, Sangeetha Poongunam
AU - Chuah, Sai Wei
AU - Leong, Rupert
AU - Kong, Chris
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Background: Inflammatory bowel disease (IBD) frequently results in disability. The relevance of psychological effects in causing disability, and whether disability occurs similarly in non-Western cohorts is as yet unknown. Aim: We assessed the relationship between symptoms of anxiety and depression, quality of life and disability in a Singaporean IBD cohort and their predictors. Methods: Cross-sectional study. We assessed consecutive IBD subjects’ IBD-Disability Index (IBD-DI), Hospital Anxiety and Depression Scale (HADS), and IBD questionnaire (IBDQ). Clinical and demographic variables were collected. Non-parametric statistical analyses were performed. Independent predictors of disability were identified through multivariate logistic regression. Results: 200 consecutive subjects were recruited (males: 69%; median age: 43.8 (±15.4) years; 95 had Crohn's disease (CD), 105 had ulcerative colitis (UC); median IBD duration: 10.8 (±9.0) years.) 27% of the cohort had anxiety and/or depression, which worsened disability (IBD-DI: −9 (±14) with anxiety vs 6 (±13) without anxiety, P < 0.001; −12 (±16) with depression vs 5 (±13) without depression, P < 0.001). Age at diagnosis, use of prednisolone, stricturing CD and active IBD were significant predictors of disability. IBDQ strongly correlated with IBD-DI(rs = 0.82, P < 0.01). Conclusion: Symptoms of anxiety and depression were common in this Asian cohort of IBD and were strongly associated with IBD-related disability. Recognizing psychological issues contributing to disability in IBD is important to ensure holistic care and appropriate treatment.
AB - Background: Inflammatory bowel disease (IBD) frequently results in disability. The relevance of psychological effects in causing disability, and whether disability occurs similarly in non-Western cohorts is as yet unknown. Aim: We assessed the relationship between symptoms of anxiety and depression, quality of life and disability in a Singaporean IBD cohort and their predictors. Methods: Cross-sectional study. We assessed consecutive IBD subjects’ IBD-Disability Index (IBD-DI), Hospital Anxiety and Depression Scale (HADS), and IBD questionnaire (IBDQ). Clinical and demographic variables were collected. Non-parametric statistical analyses were performed. Independent predictors of disability were identified through multivariate logistic regression. Results: 200 consecutive subjects were recruited (males: 69%; median age: 43.8 (±15.4) years; 95 had Crohn's disease (CD), 105 had ulcerative colitis (UC); median IBD duration: 10.8 (±9.0) years.) 27% of the cohort had anxiety and/or depression, which worsened disability (IBD-DI: −9 (±14) with anxiety vs 6 (±13) without anxiety, P < 0.001; −12 (±16) with depression vs 5 (±13) without depression, P < 0.001). Age at diagnosis, use of prednisolone, stricturing CD and active IBD were significant predictors of disability. IBDQ strongly correlated with IBD-DI(rs = 0.82, P < 0.01). Conclusion: Symptoms of anxiety and depression were common in this Asian cohort of IBD and were strongly associated with IBD-related disability. Recognizing psychological issues contributing to disability in IBD is important to ensure holistic care and appropriate treatment.
KW - Anxiety
KW - Depression
KW - Disability
KW - Inflammatory bowel disease
UR - http://www.scopus.com/inward/record.url?scp=85028726420&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2017.08.020
DO - 10.1016/j.dld.2017.08.020
M3 - Article
C2 - 28882540
AN - SCOPUS:85028726420
SN - 1590-8658
VL - 49
SP - 1314
EP - 1319
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 12
ER -