Synchronous operable pancreatic and breast cancer without genetic mutation: a literature review and discussion

Adam Ofri*, Danika Zuidersma, Connie I. Diakos, Amanda Stevanovic, Matthew Wong, Samriti Sood, Jaswinder S. Samra, Anthony J. Gill, Anubhav Mittal

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Background: Synchronous cancers are rarely detected when working-up a patient for a primary cancer. Neoadjuvant management of synchronous breast and pancreatic cancers, without a germline mutation, has yet to be discussed. Two patients were diagnosed with synchronous breast and pancreatic cancers at our institution over the last decade. A literature review was performed to evaluate the current evidence stance. Results: The first patient was 61-years old and diagnosed with a HER2+ breast cancer. The second patient was 77-years old and diagnosed with a Luminal B breast cancer. The inability to provide concurrent breast and pancreatic neoadjuvant therapy for the HER2+ patient, resulted in upfront surgery. The second patient was able to have both cancers treated simultaneously - neoadjuvant chemotherapy to the pancreas, and neoadjuvant endocrine therapy to the breast. Discuss: There is no single neoadjuvant regimen that treats both pancreatic and breast cancer. The differences in breast cancer sub-types impacted our neoadjuvant options. Our recent experience led us to the hypothesis that breast cancer care dictates treatment, while pancreatic cancer determines survival. There is a significant paucity in the literature regarding synchronous breast and pancreatic cancer.

Original languageEnglish
Article number858349
Pages (from-to)1-7
Number of pages7
JournalFrontiers in Surgery
Volume9
DOIs
Publication statusPublished - 24 Jun 2022

Bibliographical note

Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • breast cancer
  • neoadjuvant treatment
  • non-germline
  • pancreatic cancer
  • synchronous

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