Abstract
MBH is an atom efficient reaction that provides densely functionalised adducts and generates a chiral centre [1,2]. The reaction can be extremely slow and is highly substrate dependant. An appropriately positioned protic functional group within the catalyst is essential for enantioselectivity. Our aim is to establish the catalytic activity of a series of chiral [2’-diphenylphosphinoyl-[1,1]-binaphthyl] amine derivatives for the Morita-Baylis-Hillman reaction. Two synthetic approaches will be evaluated starting with 2,2’dibromo-1,1-binaphthyl; amine functionality will be introduced either through a Buchwald-Harwig [4] strategy or an intermolecular Staudinger [5] reaction.
Original language | English |
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Title of host publication | Proceedings of the NZIC 2006 |
Subtitle of host publication | back to the basics : from small molecules to materials and surfaces |
Editors | Matthias Lein |
Place of Publication | Rotorua, New Zealand |
Publisher | The New Zealand Institute of Chemistry |
Pages | 86-87 |
Number of pages | 2 |
Volume | II |
ISBN (Print) | 9780473118549 |
Publication status | Published - 2006 |
Event | New Zealand Institute of Chemistry Conference - Rotorua, New Zealand Duration: 2 Dec 2006 → 6 Dec 2006 |
Conference
Conference | New Zealand Institute of Chemistry Conference |
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City | Rotorua, New Zealand |
Period | 2/12/06 → 6/12/06 |