Synthesis and evaluation of various heteroaromatic benzamides as analogues of –ylidene-benzamide cannabinoid type 2 receptor agonists

Michael Moir, Rochelle Boyd, Hendra Gunosewoyo, Andrew P. Montgomery, Mark Connor, Michael Kassiou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The CB2 receptor is an attractive target for the treatment of a wide range of diseases and pathological conditions. Compounds that selectively activate the CB2 receptor are desirable as this avoids CB1-mediated psychoactive effects. Heteroarylidene-benzamides have demonstrated efficacy as selective CB2 receptor agonists. We aimed to expand the structure-activity relationship studies of this series of compounds by investigating the heteroaromatic core via the synthesis and in vitro evaluation of a small library of various heteroaromatic benzamide analogues. As heteroaromatic amides are privileged scaffolds in drug design, methods to synthesise them are of interest. Concise and reliable synthetic strategies were developed to access these novel analogues. The –ylidene-benzamide moiety is shown to be essential for CB activity as all amide derivatives exhibit no functional activity at either CB2 or CB1 receptors.

Original languageEnglish
Article number151019
Pages (from-to)1-7
Number of pages7
JournalTetrahedron Letters
Volume60
Issue number36
DOIs
Publication statusPublished - 5 Sep 2019

Keywords

  • Cannabinoid receptor
  • CB2
  • Heterocyclic chemistry
  • Synthesis

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