Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates

David M. McDonald, Brendan L. Wilkinson, Leo Corcilius, Morten Thaysen-Andersen, Scott N. Byrne, Richard J. Payne*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)-macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG antibodies in C57BL/6 mice after four immunisations despite the lack of a helper T cell epitope. This journal is

Original languageEnglish
Pages (from-to)10273-10276
Number of pages4
JournalChemical Communications
Volume50
Issue number71
DOIs
Publication statusPublished - 14 Sep 2014

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