Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates

David M. McDonald; Brendan L. Wilkinson; Leo Corcilius; Morten Thaysen-Andersen; Scott N. Byrne; Richard J. Payne

doi:10.1039/c4cc03510k

Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates

David M. McDonald, Brendan L. Wilkinson, Leo Corcilius, Morten Thaysen-Andersen, Scott N. Byrne, Richard J. Payne^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)-macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG antibodies in C57BL/6 mice after four immunisations despite the lack of a helper T cell epitope. This journal is

Original language	English
Pages (from-to)	10273-10276
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	71
DOIs	https://doi.org/10.1039/c4cc03510k
Publication status	Published - 14 Sept 2014

Access to Document

10.1039/c4cc03510k

Cite this

@article{88a6b57f44e24f548c5cdf4dc324d8bd,

title = "Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates",

abstract = "We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)-macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG antibodies in C57BL/6 mice after four immunisations despite the lack of a helper T cell epitope. This journal is",

author = "McDonald, \{David M.\} and Wilkinson, \{Brendan L.\} and Leo Corcilius and Morten Thaysen-Andersen and Byrne, \{Scott N.\} and Payne, \{Richard J.\}",

year = "2014",

month = sep,

day = "14",

doi = "10.1039/c4cc03510k",

language = "English",

volume = "50",

pages = "10273--10276",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "71",

}

TY - JOUR

T1 - Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates

AU - McDonald, David M.

AU - Wilkinson, Brendan L.

AU - Corcilius, Leo

AU - Thaysen-Andersen, Morten

AU - Byrne, Scott N.

AU - Payne, Richard J.

PY - 2014/9/14

Y1 - 2014/9/14

N2 - We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)-macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG antibodies in C57BL/6 mice after four immunisations despite the lack of a helper T cell epitope. This journal is

AB - We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)-macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG antibodies in C57BL/6 mice after four immunisations despite the lack of a helper T cell epitope. This journal is

UR - https://www.scopus.com/pages/publications/84905757864

U2 - 10.1039/c4cc03510k

DO - 10.1039/c4cc03510k

M3 - Article

C2 - 25056269

AN - SCOPUS:84905757864

SN - 1359-7345

VL - 50

SP - 10273

EP - 10276

JO - Chemical Communications

JF - Chemical Communications

IS - 71

ER -

Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates

Abstract

Access to Document

Other files and links

Fingerprint

Cite this