Synthesis of (2H5) indole‐3‐pyruvic acid

Jane Badenoch‐Jones*, Roger E. Summons, David S. Letham

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)


    A method for the synthesis of deuterium‐labelled tryptophan and its enzymatic conversion to indole‐3‐pyruvic acid ((2H5)IPYA) using amino acid oxidase is described. (2H5)IPYA can be used as an internal standard for the quantitation of IPYA by mass spectrometry in plant extracts and for estimating the breakdown of IPYA to indole‐3‐acetic acid (IAA) during sample extraction and purification. When used in conjunction with (2H2) IAA, (2H5) IPYA should allow more accurate quantitation of IAA in plant extracts.

    Original languageEnglish
    Pages (from-to)1325-1330
    Number of pages6
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Issue number12
    Publication statusPublished - 1983


    • deuterium‐labelled indole‐3‐pyruvic acid
    • indole‐3‐acetic acid
    • mass spectrometry


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