Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by L-cysteine methyl ester

Sarah J. Yousouf; Craig R. Brodie; Nial J. Wheate; Janice R. Aldrich-Wright

doi:10.1016/j.poly.2006.06.004

Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by L-cysteine methyl ester

Sarah J. Yousouf, Craig R. Brodie, Nial J. Wheate, Janice R. Aldrich-Wright

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A potential anticancer heterodinuclear ruthenium(II)–platinum(II) complex, [ruthenium(II)(4,4′-dimethyl-2,2′-bipyridine)₂(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH₃)₂Cl]Cl₃, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their Δ- and Λ-isomers by column chromatography, the dinuclear complex was synthesised and characterised by ¹H and ¹³C NMR, UV–Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.

Original language	English
Pages (from-to)	318-328
Number of pages	11
Journal	Polyhedron
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.poly.2006.06.004
Publication status	Published - 22 Jan 2007
Externally published	Yes

Keywords

L-cysteine methyl ester
Anticancer
Heterodinuclear
Phenanthroline
Platinum(II)
Ruthenium(II)

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title = "Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by L-cysteine methyl ester",

abstract = "A potential anticancer heterodinuclear ruthenium(II)–platinum(II) complex, [ruthenium(II)(4,4′-dimethyl-2,2′-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their Δ- and Λ-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UV–Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.",

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author = "Yousouf, \{Sarah J.\} and Brodie, \{Craig R.\} and Wheate, \{Nial J.\} and Aldrich-Wright, \{Janice R.\}",

year = "2007",

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doi = "10.1016/j.poly.2006.06.004",

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journal = "Polyhedron",

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AU - Yousouf, Sarah J.

AU - Brodie, Craig R.

AU - Wheate, Nial J.

AU - Aldrich-Wright, Janice R.

PY - 2007/1/22

Y1 - 2007/1/22

N2 - A potential anticancer heterodinuclear ruthenium(II)–platinum(II) complex, [ruthenium(II)(4,4′-dimethyl-2,2′-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their Δ- and Λ-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UV–Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.

AB - A potential anticancer heterodinuclear ruthenium(II)–platinum(II) complex, [ruthenium(II)(4,4′-dimethyl-2,2′-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their Δ- and Λ-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UV–Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.

KW - L-cysteine methyl ester

KW - Anticancer

KW - Heterodinuclear

KW - Phenanthroline

KW - Platinum(II)

KW - Ruthenium(II)

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SN - 0277-5387

VL - 26

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JO - Polyhedron

JF - Polyhedron

IS - 2

ER -

Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by L-cysteine methyl ester

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Keywords

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