Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics

Andrew M. Piggott; Peter Karuso

doi:10.1016/j.tetlet.2005.09.077

Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics

Andrew M. Piggott, Peter Karuso^*

^*Corresponding author for this work

Department of Molecular Sciences

Research output: Contribution to journal › Article

22 Citations (Scopus)

Abstract

Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for constructing affinity supports for use in chemical proteomics. The rates of photolysis of the linker on exposure to UV light emitting diodes are reported.

Original language	English
Pages (from-to)	8241-8244
Number of pages	4
Journal	Tetrahedron Letters
Volume	46
Issue number	47
DOIs	https://doi.org/10.1016/j.tetlet.2005.09.077
Publication status	Published - 21 Nov 2005

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title = "Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics",

abstract = "Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for constructing affinity supports for use in chemical proteomics. The rates of photolysis of the linker on exposure to UV light emitting diodes are reported.",

author = "Piggott, {Andrew M.} and Peter Karuso",

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AU - Piggott, Andrew M.

AU - Karuso, Peter

PY - 2005/11/21

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N2 - Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for constructing affinity supports for use in chemical proteomics. The rates of photolysis of the linker on exposure to UV light emitting diodes are reported.

AB - Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for constructing affinity supports for use in chemical proteomics. The rates of photolysis of the linker on exposure to UV light emitting diodes are reported.

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EP - 8244

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

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