Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for constructing affinity supports for use in chemical proteomics. The rates of photolysis of the linker on exposure to UV light emitting diodes are reported.

LanguageEnglish
Pages8241-8244
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number47
DOIs
Publication statusPublished - 21 Nov 2005

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Solid-Phase Synthesis Techniques
Photolysis
Ultraviolet Rays
Proteomics
Biological systems
Ultraviolet radiation
Diodes

Cite this

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title = "Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics",
abstract = "Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for constructing affinity supports for use in chemical proteomics. The rates of photolysis of the linker on exposure to UV light emitting diodes are reported.",
author = "Piggott, {Andrew M.} and Peter Karuso",
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Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics. / Piggott, Andrew M.; Karuso, Peter.

In: Tetrahedron Letters, Vol. 46, No. 47, 21.11.2005, p. 8241-8244.

Research output: Contribution to journalArticleResearchpeer-review

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