Abstract
Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for constructing affinity supports for use in chemical proteomics. The rates of photolysis of the linker on exposure to UV light emitting diodes are reported.
| Language | English |
|---|---|
| Pages | 8241-8244 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 46 |
| Issue number | 47 |
| DOIs | |
| Publication status | Published - 21 Nov 2005 |
Fingerprint
Cite this
}
Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics. / Piggott, Andrew M.; Karuso, Peter.
In: Tetrahedron Letters, Vol. 46, No. 47, 21.11.2005, p. 8241-8244.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics
AU - Piggott, Andrew M.
AU - Karuso, Peter
PY - 2005/11/21
Y1 - 2005/11/21
N2 - Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for constructing affinity supports for use in chemical proteomics. The rates of photolysis of the linker on exposure to UV light emitting diodes are reported.
AB - Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for constructing affinity supports for use in chemical proteomics. The rates of photolysis of the linker on exposure to UV light emitting diodes are reported.
UR - http://www.scopus.com/inward/record.url?scp=27144446137&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2005.09.077
DO - 10.1016/j.tetlet.2005.09.077
M3 - Article
VL - 46
SP - 8241
EP - 8244
JO - Tetrahedron Letters
T2 - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 47
ER -