Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics

Andrew M. Piggott, Peter Karuso*

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for constructing affinity supports for use in chemical proteomics. The rates of photolysis of the linker on exposure to UV light emitting diodes are reported.

Original languageEnglish
Pages (from-to)8241-8244
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number47
DOIs
Publication statusPublished - 21 Nov 2005

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