Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics

Andrew M. Piggott, Peter Karuso*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    23 Citations (Scopus)

    Abstract

    Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for constructing affinity supports for use in chemical proteomics. The rates of photolysis of the linker on exposure to UV light emitting diodes are reported.

    Original languageEnglish
    Pages (from-to)8241-8244
    Number of pages4
    JournalTetrahedron Letters
    Volume46
    Issue number47
    DOIs
    Publication statusPublished - 21 Nov 2005

    Fingerprint

    Dive into the research topics of 'Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics'. Together they form a unique fingerprint.

    Cite this