Synthesis of co-polymeric network of carbopol-g-methacrylic acid nanogels drug carrier system for gastro-protective delivery of ketoprofen and its evaluation

Rai Muhammad Sarfraz*, Muhammad Usman Khan, Asif Mahmood, Muhammad Rouf Akram, Muhammad Usman Minhas, Muhammad Naeem QAISAR, Muhammad Rizwan ALI, Hasnain Ahmad, Muhammad Zaman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Hydrogels nanoparticles of carbopol were prepared by free-radical polymerization technique. Methacrylic acid (MAA) imparted the pH-sensitive response to formulations. pH-sensitive behavior of the prepared formulations was evaluated by swelling index of the formulations at different pH 1.2 and 7.4 and it presented the maximum swelling index at pH 7.4. It was evident from the release behavior of drugs that maximum drug release was at higher pH 7.4, and less drug release at lower pH 1.2 that is acidic. Results of nanogels carrier systems are the indications of gastro-protective drug delivery of gastric irritant agent, ketoprofen.

Original languageEnglish
Pages (from-to)1109-1123
Number of pages15
JournalPolymer-Plastics Technology and Materials
Volume59
Issue number10
Early online date29 Jan 2020
DOIs
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • Carbopol
  • free radical polymerization
  • ketoprofen
  • methacrylic acid
  • nanogels

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