TY - JOUR
T1 - Synthesis of co-polymeric network of carbopol-g-methacrylic acid nanogels drug carrier system for gastro-protective delivery of ketoprofen and its evaluation
AU - Sarfraz, Rai Muhammad
AU - Khan, Muhammad Usman
AU - Mahmood, Asif
AU - Akram, Muhammad Rouf
AU - Minhas, Muhammad Usman
AU - QAISAR, Muhammad Naeem
AU - ALI, Muhammad Rizwan
AU - Ahmad, Hasnain
AU - Zaman, Muhammad
PY - 2020
Y1 - 2020
N2 - Hydrogels nanoparticles of carbopol were prepared by free-radical polymerization technique. Methacrylic acid (MAA) imparted the pH-sensitive response to formulations. pH-sensitive behavior of the prepared formulations was evaluated by swelling index of the formulations at different pH 1.2 and 7.4 and it presented the maximum swelling index at pH 7.4. It was evident from the release behavior of drugs that maximum drug release was at higher pH 7.4, and less drug release at lower pH 1.2 that is acidic. Results of nanogels carrier systems are the indications of gastro-protective drug delivery of gastric irritant agent, ketoprofen.
AB - Hydrogels nanoparticles of carbopol were prepared by free-radical polymerization technique. Methacrylic acid (MAA) imparted the pH-sensitive response to formulations. pH-sensitive behavior of the prepared formulations was evaluated by swelling index of the formulations at different pH 1.2 and 7.4 and it presented the maximum swelling index at pH 7.4. It was evident from the release behavior of drugs that maximum drug release was at higher pH 7.4, and less drug release at lower pH 1.2 that is acidic. Results of nanogels carrier systems are the indications of gastro-protective drug delivery of gastric irritant agent, ketoprofen.
KW - Carbopol
KW - free radical polymerization
KW - ketoprofen
KW - methacrylic acid
KW - nanogels
UR - http://www.scopus.com/inward/record.url?scp=85078721322&partnerID=8YFLogxK
U2 - 10.1080/25740881.2020.1719148
DO - 10.1080/25740881.2020.1719148
M3 - Article
SN - 2574-0881
VL - 59
SP - 1109
EP - 1123
JO - Polymer-Plastics Technology and Materials
JF - Polymer-Plastics Technology and Materials
IS - 10
ER -