Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy

Dima Al Sheikha, Brendan L. Wilkinson, Gajan Santhakumar, Morten Thaysen-Andersen, Richard J. Payne*

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The efficient synthesis of homogeneous MUC1 peptide oligomers using sequential ligation reactions in the N-to-C and C-to-N directions is reported. The bi-directional ligation strategy makes use of thioester formation via N → S acyl shift chemistry in combination with peptide ligation reactions and was used to prepare a library of peptide oligomers ranging in molecular mass from 3.8-9.4 kDa, comprised of between 2 and 5 repeats of the MUC1 variable number tandem repeat sequence.

Original languageEnglish
Pages (from-to)6090-6096
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number36
DOIs
Publication statusPublished - 28 Sep 2013

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