Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy

Dima Al Sheikha; Brendan L. Wilkinson; Gajan Santhakumar; Morten Thaysen-Andersen; Richard J. Payne

doi:10.1039/c3ob41363b

Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy

Dima Al Sheikha, Brendan L. Wilkinson, Gajan Santhakumar, Morten Thaysen-Andersen, Richard J. Payne^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The efficient synthesis of homogeneous MUC1 peptide oligomers using sequential ligation reactions in the N-to-C and C-to-N directions is reported. The bi-directional ligation strategy makes use of thioester formation via N → S acyl shift chemistry in combination with peptide ligation reactions and was used to prepare a library of peptide oligomers ranging in molecular mass from 3.8-9.4 kDa, comprised of between 2 and 5 repeats of the MUC1 variable number tandem repeat sequence.

Original language	English
Pages (from-to)	6090-6096
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	11
Issue number	36
DOIs	https://doi.org/10.1039/c3ob41363b
Publication status	Published - 28 Sept 2013

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abstract = "The efficient synthesis of homogeneous MUC1 peptide oligomers using sequential ligation reactions in the N-to-C and C-to-N directions is reported. The bi-directional ligation strategy makes use of thioester formation via N → S acyl shift chemistry in combination with peptide ligation reactions and was used to prepare a library of peptide oligomers ranging in molecular mass from 3.8-9.4 kDa, comprised of between 2 and 5 repeats of the MUC1 variable number tandem repeat sequence.",

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AU - Al Sheikha, Dima

AU - Wilkinson, Brendan L.

AU - Santhakumar, Gajan

AU - Thaysen-Andersen, Morten

AU - Payne, Richard J.

PY - 2013/9/28

Y1 - 2013/9/28

N2 - The efficient synthesis of homogeneous MUC1 peptide oligomers using sequential ligation reactions in the N-to-C and C-to-N directions is reported. The bi-directional ligation strategy makes use of thioester formation via N → S acyl shift chemistry in combination with peptide ligation reactions and was used to prepare a library of peptide oligomers ranging in molecular mass from 3.8-9.4 kDa, comprised of between 2 and 5 repeats of the MUC1 variable number tandem repeat sequence.

AB - The efficient synthesis of homogeneous MUC1 peptide oligomers using sequential ligation reactions in the N-to-C and C-to-N directions is reported. The bi-directional ligation strategy makes use of thioester formation via N → S acyl shift chemistry in combination with peptide ligation reactions and was used to prepare a library of peptide oligomers ranging in molecular mass from 3.8-9.4 kDa, comprised of between 2 and 5 repeats of the MUC1 variable number tandem repeat sequence.

UR - https://www.scopus.com/pages/publications/84882978971

U2 - 10.1039/c3ob41363b

DO - 10.1039/c3ob41363b

M3 - Article

C2 - 23922001

AN - SCOPUS:84882978971

SN - 1477-0520

VL - 11

SP - 6090

EP - 6096

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 36

ER -

Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy

Abstract

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