Synthesis of the cyclic heptapeptide axinellin A

Kelly A. Fairweather, Nima Sayyadi, Christos Roussakis, Katrina A. Jolliffe*

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The first synthesis of the naturally occurring cyclic peptide axinellin A has been achieved. Cyclization and subsequent deprotection of linear precursors containing either a t-butyl protected Thr residue or a Thr(ΨMe,Mepro) derivative gave a cyclic peptide, identical in all respects to the naturally occurring material, with the exception that the synthetic peptide does not exhibit the cytotoxic activity reported for the natural product.

Original languageEnglish
Pages (from-to)935-939
Number of pages5
JournalTetrahedron
Volume66
Issue number4
DOIs
Publication statusPublished - 23 Jan 2010
Externally publishedYes

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