Systematic review and meta-analysis: prevalence of small intestinal bacterial overgrowth in chronic liver disease

Ayesha Shah, Erin Shanahan, Graeme A. Macdonald, Linda Fletcher, Pegah Ghasemi, Mark Morrison, Mike Jones, Gerald Holtmann

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

The authors conducted a meta-analysis of the prevalence of small intestinal bacterial overgrowth (SIBO) in patients with chronic liver disease (CLD) and controls. Using the search terms small intestinal bacterial overgrowth (SIBO) and chronic liver disease (CLD) or cirrhosis, 19 case-control studies were identified. Utilizing breath tests, the prevalence of SIBO in CLD was 35.80% (95% CI, 32.60-39.10) compared with 8.0% (95% CI, 5.70-11.00) in controls. Using culture techniques, the prevalence was 68.31% (95% CI, 59.62-76.00) in CLD patients as compared with 7.94% (95% CI, 3.44-12.73) in controls. No difference between cirrhotic and noncirrhotic patients was found. SIBO is significantly more frequent in CLD patients as compared with controls. The association of SIBO and CLD was not confined to patients with advanced CLD, suggesting that SIBO is not a consequence of advanced liver disease but may play a role in the progression of CLD.

LanguageEnglish
Pages388-400
Number of pages13
JournalSeminars in Liver Disease
Volume37
Issue number4
DOIs
Publication statusPublished - 2017

Fingerprint

Meta-Analysis
Liver Diseases
Chronic Disease
Culture Techniques
Breath Tests
Liver Cirrhosis
Case-Control Studies

Keywords

  • cirrhosis
  • bacterial overgrowth
  • prevalence
  • breath tests
  • NAFLD

Cite this

Shah, A., Shanahan, E., Macdonald, G. A., Fletcher, L., Ghasemi, P., Morrison, M., ... Holtmann, G. (2017). Systematic review and meta-analysis: prevalence of small intestinal bacterial overgrowth in chronic liver disease. Seminars in Liver Disease, 37(4), 388-400. https://doi.org/10.1055/s-0037-1608832
Shah, Ayesha ; Shanahan, Erin ; Macdonald, Graeme A. ; Fletcher, Linda ; Ghasemi, Pegah ; Morrison, Mark ; Jones, Mike ; Holtmann, Gerald. / Systematic review and meta-analysis : prevalence of small intestinal bacterial overgrowth in chronic liver disease. In: Seminars in Liver Disease. 2017 ; Vol. 37, No. 4. pp. 388-400.
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Shah, A, Shanahan, E, Macdonald, GA, Fletcher, L, Ghasemi, P, Morrison, M, Jones, M & Holtmann, G 2017, 'Systematic review and meta-analysis: prevalence of small intestinal bacterial overgrowth in chronic liver disease', Seminars in Liver Disease, vol. 37, no. 4, pp. 388-400. https://doi.org/10.1055/s-0037-1608832

Systematic review and meta-analysis : prevalence of small intestinal bacterial overgrowth in chronic liver disease. / Shah, Ayesha; Shanahan, Erin; Macdonald, Graeme A.; Fletcher, Linda; Ghasemi, Pegah; Morrison, Mark; Jones, Mike; Holtmann, Gerald.

In: Seminars in Liver Disease, Vol. 37, No. 4, 2017, p. 388-400.

Research output: Contribution to journalReview articleResearchpeer-review

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AU - Holtmann, Gerald

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