TY - JOUR
T1 - Systematic review and meta-analysis
T2 - prevalence of small intestinal bacterial overgrowth in chronic liver disease
AU - Shah, Ayesha
AU - Shanahan, Erin
AU - Macdonald, Graeme A.
AU - Fletcher, Linda
AU - Ghasemi, Pegah
AU - Morrison, Mark
AU - Jones, Mike
AU - Holtmann, Gerald
PY - 2017
Y1 - 2017
N2 - The authors conducted a meta-analysis of the prevalence of small intestinal bacterial overgrowth (SIBO) in patients with chronic liver disease (CLD) and controls. Using the search terms small intestinal bacterial overgrowth (SIBO) and chronic liver disease (CLD) or cirrhosis, 19 case-control studies were identified. Utilizing breath tests, the prevalence of SIBO in CLD was 35.80% (95% CI, 32.60-39.10) compared with 8.0% (95% CI, 5.70-11.00) in controls. Using culture techniques, the prevalence was 68.31% (95% CI, 59.62-76.00) in CLD patients as compared with 7.94% (95% CI, 3.44-12.73) in controls. No difference between cirrhotic and noncirrhotic patients was found. SIBO is significantly more frequent in CLD patients as compared with controls. The association of SIBO and CLD was not confined to patients with advanced CLD, suggesting that SIBO is not a consequence of advanced liver disease but may play a role in the progression of CLD.
AB - The authors conducted a meta-analysis of the prevalence of small intestinal bacterial overgrowth (SIBO) in patients with chronic liver disease (CLD) and controls. Using the search terms small intestinal bacterial overgrowth (SIBO) and chronic liver disease (CLD) or cirrhosis, 19 case-control studies were identified. Utilizing breath tests, the prevalence of SIBO in CLD was 35.80% (95% CI, 32.60-39.10) compared with 8.0% (95% CI, 5.70-11.00) in controls. Using culture techniques, the prevalence was 68.31% (95% CI, 59.62-76.00) in CLD patients as compared with 7.94% (95% CI, 3.44-12.73) in controls. No difference between cirrhotic and noncirrhotic patients was found. SIBO is significantly more frequent in CLD patients as compared with controls. The association of SIBO and CLD was not confined to patients with advanced CLD, suggesting that SIBO is not a consequence of advanced liver disease but may play a role in the progression of CLD.
KW - cirrhosis
KW - bacterial overgrowth
KW - prevalence
KW - breath tests
KW - NAFLD
UR - http://www.scopus.com/inward/record.url?scp=85039160629&partnerID=8YFLogxK
U2 - 10.1055/s-0037-1608832
DO - 10.1055/s-0037-1608832
M3 - Review article
C2 - 29272899
AN - SCOPUS:85039160629
SN - 0272-8087
VL - 37
SP - 388
EP - 400
JO - Seminars in Liver Disease
JF - Seminars in Liver Disease
IS - 4
ER -