Systemic inflammation and cognition in the elderly

Julian Trollor*, Emmeline Agars

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Citations (Scopus)


A complex inflammatory cascade is an established part of the pathophysiology of Alzheimer's disease (AD), and preliminary studies have suggested a link between systemic inflammation and AD. Recent research has extended this theme by examining the influence of systemic inflammation on cognitive function in community-dwelling elderly. Preliminary findings suggest that elevated levels of some inflammatory markers such as interleukin-6 (IL-6) and C-reactive protein (CRP) are associated with poorer cognition at cross-sectional assessment. Longitudinal studies suggest an impact of raised IL-6 and CRP, in terms of both cognitive decline and outcome of dementia. Although findings vary considerably between studies, systemic inflammation may have relevance for cognitive function and cognitive decline in late life. Further comprehensive studies are required to further explore the relationship between systemic inflammation and cognition in the elderly.

Original languageEnglish
Title of host publicationNeuropsychiatric Disorders
EditorsKoho Miyoshi, Yasushi Morimura, Kyoshi Maeda
Place of PublicationTokyo
PublisherSpringer, Springer Nature
Number of pages21
ISBN (Electronic)9784431538714
ISBN (Print)9784431538707, 4431538704
Publication statusPublished - 2010
Externally publishedYes


  • Cognition
  • Cytokines
  • Dementia
  • Inflammation
  • Mild cognitive impairment


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