Systems biology as a platform for wine yeast strain development

Anthony R. Borneman; Paul J. Chambers; Isak S. Pretorius

doi:10.1007/978-3-540-85463-0_22

Systems biology as a platform for wine yeast strain development

Anthony R. Borneman, Paul J. Chambers, Isak S. Pretorius^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Citations (Scopus)

Abstract

Over thousands of years, large numbers of Saccharomyces cerevisiae strains have been inadvertently and deliberately isolated for their desirable winemaking properties. In the latter part of the twentieth century, many of these wine yeast strains were improved using classical genetic approaches such as breeding, mutagenesis, and adaptive evolution, and, in more recent times, recombinant DNA methods. Now we are in the midst of the 'omics revolution, which promises, with the aid of mathematical modelling, a 'complete' understanding of cells in all their complexity. Known as systems biology, this approach will enable strain development with unmatched precision and speed, and facilitate the tailoring of yeast metabolism to meet the ever-increasing demands and preferences of winemakers and consumers.

Original language	English
Title of host publication	Biology of microorganisms on grapes, in must and in wine
Editors	Helmut König, Gottfried Unden, Jürgen Fröhlich
Place of Publication	Berlin
Publisher	Springer, Springer Nature
Pages	395-414
Number of pages	20
ISBN (Electronic)	9783540854630
ISBN (Print)	9783540854623
DOIs	https://doi.org/10.1007/978-3-540-85463-0_22
Publication status	Published - 2009
Externally published	Yes

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10.1007/978-3-540-85463-0_22

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title = "Systems biology as a platform for wine yeast strain development",

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Systems biology as a platform for wine yeast strain development. / Borneman, Anthony R.; Chambers, Paul J.; Pretorius, Isak S.
Biology of microorganisms on grapes, in must and in wine. ed. / Helmut König; Gottfried Unden; Jürgen Fröhlich. Berlin: Springer, Springer Nature, 2009. p. 395-414.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AB - Over thousands of years, large numbers of Saccharomyces cerevisiae strains have been inadvertently and deliberately isolated for their desirable winemaking properties. In the latter part of the twentieth century, many of these wine yeast strains were improved using classical genetic approaches such as breeding, mutagenesis, and adaptive evolution, and, in more recent times, recombinant DNA methods. Now we are in the midst of the 'omics revolution, which promises, with the aid of mathematical modelling, a 'complete' understanding of cells in all their complexity. Known as systems biology, this approach will enable strain development with unmatched precision and speed, and facilitate the tailoring of yeast metabolism to meet the ever-increasing demands and preferences of winemakers and consumers.

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A2 - Unden, Gottfried

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Systems biology as a platform for wine yeast strain development

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