Tackling gender in progressive supranuclear palsy: male patients present more apathy

Lan Ye; Stephan Greten; Ida Wilkens; Florian Wegner; Lea Krey; Matthias Höllerhage; Monika Pötter-Nerger; Molly Zeitzschel; Keno Hagena; Jan Kassubek; Patrick Süß; Jürgen Winkler; Daniela Berg; Steffen Paschen; Lars Tönges; Doreen Gruber; Florin Gandor; Wolfgang H. Jost; Andrea A Kühn; Inga Claus; Tobias Warnecke; David J. Pedrosa; Carsten Eggers; Claudia Trenkwalder; Joseph Classen; Johannes Schwarz; Alfons Schnitzler; Günter U. Höglinger; Martin Klietz

doi:10.1177/1877718X251343094

Tackling gender in progressive supranuclear palsy: male patients present more apathy

Lan Ye, Stephan Greten, Ida Wilkens, Florian Wegner, Lea Krey, Matthias Höllerhage, Monika Pötter-Nerger, Molly Zeitzschel, Keno Hagena, Jan Kassubek, Patrick Süß, Jürgen Winkler, Daniela Berg, Steffen Paschen, Lars Tönges, Doreen Gruber, Florin Gandor, Wolfgang H. Jost, Andrea A Kühn, Inga ClausTobias Warnecke, David J. Pedrosa, Carsten Eggers, Claudia Trenkwalder, Joseph Classen, Johannes Schwarz, Alfons Schnitzler, Günter U. Höglinger, Martin Klietz

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Abstract

Gender differences in progressive supranuclear palsy (PSP) may become relevant for clinical trials, treatment decisions and patient counseling. To study gender associated differences we conducted a retrospective data analysis of 191 male and 157 female PSP patients from a large multicenter observational cohort in Germany. While no differences in motor skills, disease severity, daily living abilities, global cognitive status and depressive symptoms were observed between genders, male patients showed significantly higher apathy scores, a finding also noted in other neurological diseases. In this study, apart from male patients exhibiting higher levels of apathy, no significant disease-specific gender differences were observed in PSP patients.

Original language	English
Pages (from-to)	1024-1028
Number of pages	5
Journal	Journal of Parkinson's Disease
Volume	15
Issue number	5
Early online date	4 Jun 2025
DOIs	https://doi.org/10.1177/1877718X251343094
Publication status	Published - Aug 2025
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2025. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

progressive supranuclear palsy
gender
apathy

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10.1177/1877718X251343094Licence: CC BY-NC

Publisher version (open access)Final published version, 1.77 MBLicence: CC BY-NC

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Ye, L., Greten, S., Wilkens, I., Wegner, F., Krey, L., Höllerhage, M., Pötter-Nerger, M., Zeitzschel, M., Hagena, K., Kassubek, J., Süß, P., Winkler, J., Berg, D., Paschen, S., Tönges, L., Gruber, D., Gandor, F., Jost, W. H., Kühn, A. A., ... Klietz, M. (2025). Tackling gender in progressive supranuclear palsy: male patients present more apathy. Journal of Parkinson's Disease, 15(5), 1024-1028. https://doi.org/10.1177/1877718X251343094

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title = "Tackling gender in progressive supranuclear palsy: male patients present more apathy",

abstract = "Gender differences in progressive supranuclear palsy (PSP) may become relevant for clinical trials, treatment decisions and patient counseling. To study gender associated differences we conducted a retrospective data analysis of 191 male and 157 female PSP patients from a large multicenter observational cohort in Germany. While no differences in motor skills, disease severity, daily living abilities, global cognitive status and depressive symptoms were observed between genders, male patients showed significantly higher apathy scores, a finding also noted in other neurological diseases. In this study, apart from male patients exhibiting higher levels of apathy, no significant disease-specific gender differences were observed in PSP patients.",

keywords = "progressive supranuclear palsy, gender, apathy",

author = "Lan Ye and Stephan Greten and Ida Wilkens and Florian Wegner and Lea Krey and Matthias H{\"o}llerhage and Monika P{\"o}tter-Nerger and Molly Zeitzschel and Keno Hagena and Jan Kassubek and Patrick S{\"u}{\ss} and J{\"u}rgen Winkler and Daniela Berg and Steffen Paschen and Lars T{\"o}nges and Doreen Gruber and Florin Gandor and Jost, {Wolfgang H.} and K{\"u}hn, {Andrea A} and Inga Claus and Tobias Warnecke and Pedrosa, {David J.} and Carsten Eggers and Claudia Trenkwalder and Joseph Classen and Johannes Schwarz and Alfons Schnitzler and H{\"o}glinger, {G{\"u}nter U.} and Martin Klietz",

note = "Copyright the Author(s) 2025. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2025",

month = aug,

doi = "10.1177/1877718X251343094",

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Ye, L, Greten, S, Wilkens, I, Wegner, F, Krey, L, Höllerhage, M, Pötter-Nerger, M, Zeitzschel, M, Hagena, K, Kassubek, J, Süß, P, Winkler, J, Berg, D, Paschen, S, Tönges, L, Gruber, D, Gandor, F, Jost, WH, Kühn, AA, Claus, I, Warnecke, T, Pedrosa, DJ, Eggers, C, Trenkwalder, C, Classen, J, Schwarz, J, Schnitzler, A, Höglinger, GU & Klietz, M 2025, 'Tackling gender in progressive supranuclear palsy: male patients present more apathy', Journal of Parkinson's Disease, vol. 15, no. 5, pp. 1024-1028. https://doi.org/10.1177/1877718X251343094

TY - JOUR

T1 - Tackling gender in progressive supranuclear palsy

T2 - male patients present more apathy

AU - Ye, Lan

AU - Greten, Stephan

AU - Wilkens, Ida

AU - Wegner, Florian

AU - Krey, Lea

AU - Höllerhage, Matthias

AU - Pötter-Nerger, Monika

AU - Zeitzschel, Molly

AU - Hagena, Keno

AU - Kassubek, Jan

AU - Süß, Patrick

AU - Winkler, Jürgen

AU - Berg, Daniela

AU - Paschen, Steffen

AU - Tönges, Lars

AU - Gruber, Doreen

AU - Gandor, Florin

AU - Jost, Wolfgang H.

AU - Kühn, Andrea A

AU - Claus, Inga

AU - Warnecke, Tobias

AU - Pedrosa, David J.

AU - Eggers, Carsten

AU - Trenkwalder, Claudia

AU - Classen, Joseph

AU - Schwarz, Johannes

AU - Schnitzler, Alfons

AU - Höglinger, Günter U.

AU - Klietz, Martin

N1 - Copyright the Author(s) 2025. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2025/8

Y1 - 2025/8

N2 - Gender differences in progressive supranuclear palsy (PSP) may become relevant for clinical trials, treatment decisions and patient counseling. To study gender associated differences we conducted a retrospective data analysis of 191 male and 157 female PSP patients from a large multicenter observational cohort in Germany. While no differences in motor skills, disease severity, daily living abilities, global cognitive status and depressive symptoms were observed between genders, male patients showed significantly higher apathy scores, a finding also noted in other neurological diseases. In this study, apart from male patients exhibiting higher levels of apathy, no significant disease-specific gender differences were observed in PSP patients.

AB - Gender differences in progressive supranuclear palsy (PSP) may become relevant for clinical trials, treatment decisions and patient counseling. To study gender associated differences we conducted a retrospective data analysis of 191 male and 157 female PSP patients from a large multicenter observational cohort in Germany. While no differences in motor skills, disease severity, daily living abilities, global cognitive status and depressive symptoms were observed between genders, male patients showed significantly higher apathy scores, a finding also noted in other neurological diseases. In this study, apart from male patients exhibiting higher levels of apathy, no significant disease-specific gender differences were observed in PSP patients.

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KW - gender

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U2 - 10.1177/1877718X251343094

DO - 10.1177/1877718X251343094

M3 - Article

C2 - 40462618

SN - 1877-7171

VL - 15

SP - 1024

EP - 1028

JO - Journal of Parkinson's Disease

JF - Journal of Parkinson's Disease

IS - 5

ER -

Tackling gender in progressive supranuclear palsy: male patients present more apathy

Abstract

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Keywords

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