Tap and Inject versus pars plana vitrectomy for post-procedural endophthalmitis: a meta-analysis

Parsa Mehraban Far; Shanna C. Yeung; Pedram Laghaei Farimani; Jenny Qian; Angela Q. Zhang; Peter J. Kertes; Yuyi You; Peng Yan

doi:10.1097/IAE.0000000000003203

Tap and Inject versus pars plana vitrectomy for post-procedural endophthalmitis: a meta-analysis

Parsa Mehraban Far, Shanna C. Yeung, Pedram Laghaei Farimani, Jenny Qian, Angela Q. Zhang, Peter J. Kertes, Yuyi You, Peng Yan

Department of Clinical Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To compare the visual outcomes after prompt pars plana vitrectomy (PPV) with tap biopsy and intravitreal antimicrobial injection (TAI) to treat post-injection and post-surgery endophthalmitis.

Methods: The Cochrane Central Register of Controlled Trials, OVID MEDLINE, and OVID Embase databases were searched for manuscripts published between January 2010 to November 2020. Two independent reviewers selected papers and extracted data. We analyzed data in RevMan 5.3 and assessed methodological quality using the Cochrane ROBINS-I tool. Mean improvement in visual outcome was compared between PPV and TAI as a relative risk of improving >= 2 lines, and a mean LogMAR difference in improvement.

Results: 15 retrospective case-series (1355 eyes), of which 739 (55%) received TAI and 616 (45%) PPV as initial treatment were included. The overall relative risk of improving 2 or more lines in PPV in comparison to TAI was 1.04 (95% CI 0.88-1.23; p=0.61; I2=0%) with a mean difference of 0.04 (95% CI -0.18-0.27; p=0.69; I2=0%). The results stayed robust when subgroup analysis based on causative procedure for endophthalmitis was performed.

Conclusions: TAI is non-inferior to PPV for the treatment of post-cataract operation, post-injection, and post-pars plana vitrectomy endophthalmitis.

Original language	English
Journal	Retina
DOIs	https://doi.org/10.1097/IAE.0000000000003203
Publication status	E-pub ahead of print - 14 May 2021

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@article{3499e2b9d6f5485685e9c3c3610b8daa,

title = "Tap and Inject versus pars plana vitrectomy for post-procedural endophthalmitis: a meta-analysis",

abstract = "Purpose: To compare the visual outcomes after prompt pars plana vitrectomy (PPV) with tap biopsy and intravitreal antimicrobial injection (TAI) to treat post-injection and post-surgery endophthalmitis.Methods: The Cochrane Central Register of Controlled Trials, OVID MEDLINE, and OVID Embase databases were searched for manuscripts published between January 2010 to November 2020. Two independent reviewers selected papers and extracted data. We analyzed data in RevMan 5.3 and assessed methodological quality using the Cochrane ROBINS-I tool. Mean improvement in visual outcome was compared between PPV and TAI as a relative risk of improving >= 2 lines, and a mean LogMAR difference in improvement.Results: 15 retrospective case-series (1355 eyes), of which 739 (55%) received TAI and 616 (45%) PPV as initial treatment were included. The overall relative risk of improving 2 or more lines in PPV in comparison to TAI was 1.04 (95% CI 0.88-1.23; p=0.61; I2=0%) with a mean difference of 0.04 (95% CI -0.18-0.27; p=0.69; I2=0%). The results stayed robust when subgroup analysis based on causative procedure for endophthalmitis was performed.Conclusions: TAI is non-inferior to PPV for the treatment of post-cataract operation, post-injection, and post-pars plana vitrectomy endophthalmitis.",

author = "Far, {Parsa Mehraban} and Yeung, {Shanna C.} and Farimani, {Pedram Laghaei} and Jenny Qian and Zhang, {Angela Q.} and Kertes, {Peter J.} and Yuyi You and Peng Yan",

note = "Copyright {\textcopyright} 2021 by Ophthalmic Communications Society, Inc.",

year = "2021",

month = may,

day = "14",

doi = "10.1097/IAE.0000000000003203",

language = "English",

journal = "Retina",

issn = "0275-004X",

publisher = "Lippincott Williams & Wilkins",

}

TY - JOUR

T1 - Tap and Inject versus pars plana vitrectomy for post-procedural endophthalmitis

T2 - a meta-analysis

AU - Far, Parsa Mehraban

AU - Yeung, Shanna C.

AU - Farimani, Pedram Laghaei

AU - Qian, Jenny

AU - Zhang, Angela Q.

AU - Kertes, Peter J.

AU - You, Yuyi

AU - Yan, Peng

PY - 2021/5/14

Y1 - 2021/5/14

N2 - Purpose: To compare the visual outcomes after prompt pars plana vitrectomy (PPV) with tap biopsy and intravitreal antimicrobial injection (TAI) to treat post-injection and post-surgery endophthalmitis.Methods: The Cochrane Central Register of Controlled Trials, OVID MEDLINE, and OVID Embase databases were searched for manuscripts published between January 2010 to November 2020. Two independent reviewers selected papers and extracted data. We analyzed data in RevMan 5.3 and assessed methodological quality using the Cochrane ROBINS-I tool. Mean improvement in visual outcome was compared between PPV and TAI as a relative risk of improving >= 2 lines, and a mean LogMAR difference in improvement.Results: 15 retrospective case-series (1355 eyes), of which 739 (55%) received TAI and 616 (45%) PPV as initial treatment were included. The overall relative risk of improving 2 or more lines in PPV in comparison to TAI was 1.04 (95% CI 0.88-1.23; p=0.61; I2=0%) with a mean difference of 0.04 (95% CI -0.18-0.27; p=0.69; I2=0%). The results stayed robust when subgroup analysis based on causative procedure for endophthalmitis was performed.Conclusions: TAI is non-inferior to PPV for the treatment of post-cataract operation, post-injection, and post-pars plana vitrectomy endophthalmitis.

AB - Purpose: To compare the visual outcomes after prompt pars plana vitrectomy (PPV) with tap biopsy and intravitreal antimicrobial injection (TAI) to treat post-injection and post-surgery endophthalmitis.Methods: The Cochrane Central Register of Controlled Trials, OVID MEDLINE, and OVID Embase databases were searched for manuscripts published between January 2010 to November 2020. Two independent reviewers selected papers and extracted data. We analyzed data in RevMan 5.3 and assessed methodological quality using the Cochrane ROBINS-I tool. Mean improvement in visual outcome was compared between PPV and TAI as a relative risk of improving >= 2 lines, and a mean LogMAR difference in improvement.Results: 15 retrospective case-series (1355 eyes), of which 739 (55%) received TAI and 616 (45%) PPV as initial treatment were included. The overall relative risk of improving 2 or more lines in PPV in comparison to TAI was 1.04 (95% CI 0.88-1.23; p=0.61; I2=0%) with a mean difference of 0.04 (95% CI -0.18-0.27; p=0.69; I2=0%). The results stayed robust when subgroup analysis based on causative procedure for endophthalmitis was performed.Conclusions: TAI is non-inferior to PPV for the treatment of post-cataract operation, post-injection, and post-pars plana vitrectomy endophthalmitis.

U2 - 10.1097/IAE.0000000000003203

DO - 10.1097/IAE.0000000000003203

M3 - Article

C2 - 34009185

JO - Retina

JF - Retina

SN - 0275-004X

ER -

Tap and Inject versus pars plana vitrectomy for post-procedural endophthalmitis: a meta-analysis

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