Target dependence of Nissl body ultrastructure in cat thoracic motoneurones

I. P. Johnson, A. H. Pullen, T. A. Sears*

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The effects on Nissl body (NB) ultrastructure of muscle reinnervation or neuroma formation were determined in cytochemically identified cat thoracic motoneurones subjected to axotomy by either nerve crush or nerve section with proximal ligation. Normal NB ultrastructure comprised highly ordered lamellae of rough endoplasmic reticulum (RER) with associated linear arrays of unbound polyribosomes. This ultrastructural orderliness was lost following axotomy, with or without light microscopic chromatolysis. While NBs were seen in the light microscope at late stages following both nerve crush or ligation, normal NB ultrastructure was only observed following nerve crush. An inductive effect of the periphery on NB ultrastructure is proposed and the implications of NB ultrastructure discussed in relation to protein synthesis.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalNeuroscience Letters
Volume61
Issue number1-2
DOIs
Publication statusPublished - 24 Oct 1985
Externally publishedYes

Keywords

  • axotomy
  • cat
  • horseradish peroxidase
  • motoneuron
  • neuroma
  • Nissl
  • target

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