Targeted complexes based on upconversion nanoparticles for imaging in the first and second optical tissue transparency window

E. L. Guryev*, V. A. Sukhova, A. V. Yudintsev, A. B. Kostyk, A. V. Lubeshkin, J. Chen, A. V. Zvyagin

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Achieving both deep penetration of photons into biological tissue and highly sensitive recording of optical probes' response are the key goals of non-invasive optical imaging. In comparison with the traditional fluorescence imaging in the visible (400–700 nm) and near-infrared (700–900 nm) regions, optical fluorescence imaging in the second optical tissue transparency window (1000–2300 nm) demonstrates low photon scattering, deeper penetration into the tissues and lower autofluorescence. In the present study, biocompatible upconversion nanoparticles with different contents of doping lanthanides, capable of luminescence in the visible and short-wave IR regions, were obtained and characterized. Also, targeted complexes based on Gd-containing nanophosphors were obtained as potential contrast agents for magnetic resonance imaging. Selective binding of targeted complexes to the surface of tumor cells expressing the HER2 receptor was shown.

    Original languageEnglish
    Pages (from-to)12-21
    Number of pages10
    JournalOpera Medica et Physiologica
    Volume8
    Issue number1
    DOIs
    Publication statusPublished - 2021

    Keywords

    • Short-wave infrared optical imaging
    • Targeted complexes
    • Upconversion nanoparticles

    Fingerprint

    Dive into the research topics of 'Targeted complexes based on upconversion nanoparticles for imaging in the first and second optical tissue transparency window'. Together they form a unique fingerprint.

    Cite this