Targeting mTOR signaling by polyphenols

a new therapeutic target for ageing

Hamidreza Pazoki-Toroudi, Hamed Amani, Marjan Ajami, Seyed Fazel Nabavi, Nady Braidy*, Pandima Devi Kasi, Seyed Mohammad Nabavi

*Corresponding author for this work

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Current ageing research is aimed not only at the promotion of longevity, but also at improving ‎health span‎ through the‎ discovery and development‎ of new therapeutic strategies‎‏‎ by investigating ‎molecular and ‎cellular ‎pathways involved in cellular senescence.‎ Understanding the mechanism of action ‎of ‎polyphenolic compounds targeting mTOR (mechanistic target of rapamycin) and related pathways opens up new directions ‎‎to revolutionize ways to slow down the ‎onset and development of age-dependent degeneration. Herein, we will ‎discuss the mechanisms by which polyphenols can delay the‎ molecular ‎pathogenesis of ageing via manipulation or more specifically inhibition of mTOR-signaling pathways. We will also discuss the implications of polyphenols in targeting mTOR and its related ‎pathways‎‎ on ‎health life span extension and longevity.‎

Original languageEnglish
Pages (from-to)55-66
Number of pages12
JournalAgeing Research Reviews
Volume31
DOIs
Publication statusPublished - 1 Nov 2016
Externally publishedYes

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Keywords

  • Journal Article
  • Review

Cite this

Pazoki-Toroudi, H., Amani, H., Ajami, M., Nabavi, S. F., Braidy, N., Kasi, P. D., & Nabavi, S. M. (2016). Targeting mTOR signaling by polyphenols: a new therapeutic target for ageing. Ageing Research Reviews, 31, 55-66. https://doi.org/10.1016/j.arr.2016.07.004