TY - JOUR
T1 - Targeting mTOR signaling by polyphenols
T2 - a new therapeutic target for ageing
AU - Pazoki-Toroudi, Hamidreza
AU - Amani, Hamed
AU - Ajami, Marjan
AU - Nabavi, Seyed Fazel
AU - Braidy, Nady
AU - Kasi, Pandima Devi
AU - Nabavi, Seyed Mohammad
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Current ageing research is aimed not only at the promotion of longevity, but also at improving health span through the discovery and development of new therapeutic strategies by investigating molecular and cellular pathways involved in cellular senescence. Understanding the mechanism of action of polyphenolic compounds targeting mTOR (mechanistic target of rapamycin) and related pathways opens up new directions to revolutionize ways to slow down the onset and development of age-dependent degeneration. Herein, we will discuss the mechanisms by which polyphenols can delay the molecular pathogenesis of ageing via manipulation or more specifically inhibition of mTOR-signaling pathways. We will also discuss the implications of polyphenols in targeting mTOR and its related pathways on health life span extension and longevity.
AB - Current ageing research is aimed not only at the promotion of longevity, but also at improving health span through the discovery and development of new therapeutic strategies by investigating molecular and cellular pathways involved in cellular senescence. Understanding the mechanism of action of polyphenolic compounds targeting mTOR (mechanistic target of rapamycin) and related pathways opens up new directions to revolutionize ways to slow down the onset and development of age-dependent degeneration. Herein, we will discuss the mechanisms by which polyphenols can delay the molecular pathogenesis of ageing via manipulation or more specifically inhibition of mTOR-signaling pathways. We will also discuss the implications of polyphenols in targeting mTOR and its related pathways on health life span extension and longevity.
KW - Journal Article
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=84979743554&partnerID=8YFLogxK
U2 - 10.1016/j.arr.2016.07.004
DO - 10.1016/j.arr.2016.07.004
M3 - Review article
C2 - 27453478
AN - SCOPUS:84979743554
VL - 31
SP - 55
EP - 66
JO - Ageing Research Reviews
JF - Ageing Research Reviews
SN - 1568-1637
ER -