Targeting mTOR signaling by polyphenols: a new therapeutic target for ageing

Hamidreza Pazoki-Toroudi; Hamed Amani; Marjan Ajami; Seyed Fazel Nabavi; Nady Braidy; Pandima Devi Kasi; Seyed Mohammad Nabavi

doi:10.1016/j.arr.2016.07.004

Targeting mTOR signaling by polyphenols: a new therapeutic target for ageing

Hamidreza Pazoki-Toroudi
, Hamed Amani
, Marjan Ajami
, Seyed Fazel Nabavi
, Nady Braidy^*
, Pandima Devi Kasi
, Seyed Mohammad Nabavi

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

66 Citations (Scopus)

Abstract

Current ageing research is aimed not only at the promotion of longevity, but also at improving ‎health span‎ through the‎ discovery and development‎ of new therapeutic strategies‎‏‎ by investigating ‎molecular and ‎cellular ‎pathways involved in cellular senescence.‎ Understanding the mechanism of action ‎of ‎polyphenolic compounds targeting mTOR (mechanistic target of rapamycin) and related pathways opens up new directions ‎‎to revolutionize ways to slow down the ‎onset and development of age-dependent degeneration. Herein, we will ‎discuss the mechanisms by which polyphenols can delay the‎ molecular ‎pathogenesis of ageing via manipulation or more specifically inhibition of mTOR-signaling pathways. We will also discuss the implications of polyphenols in targeting mTOR and its related ‎pathways‎‎ on ‎health life span extension and longevity.‎

Original language	English
Pages (from-to)	55-66
Number of pages	12
Journal	Ageing Research Reviews
Volume	31
DOIs	https://doi.org/10.1016/j.arr.2016.07.004
Publication status	Published - 1 Nov 2016
Externally published	Yes

Keywords

Journal Article
Review

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10.1016/j.arr.2016.07.004

Cite this

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title = "Targeting mTOR signaling by polyphenols: a new therapeutic target for ageing",

abstract = "Current ageing research is aimed not only at the promotion of longevity, but also at improving ‎health span‎ through the‎ discovery and development‎ of new therapeutic strategies‎‏‎ by investigating ‎molecular and ‎cellular ‎pathways involved in cellular senescence.‎ Understanding the mechanism of action ‎of ‎polyphenolic compounds targeting mTOR (mechanistic target of rapamycin) and related pathways opens up new directions ‎‎to revolutionize ways to slow down the ‎onset and development of age-dependent degeneration. Herein, we will ‎discuss the mechanisms by which polyphenols can delay the‎ molecular ‎pathogenesis of ageing via manipulation or more specifically inhibition of mTOR-signaling pathways. We will also discuss the implications of polyphenols in targeting mTOR and its related ‎pathways‎‎ on ‎health life span extension and longevity.‎",

keywords = "Journal Article, Review",

author = "Hamidreza Pazoki-Toroudi and Hamed Amani and Marjan Ajami and Nabavi, \{Seyed Fazel\} and Nady Braidy and Kasi, \{Pandima Devi\} and Nabavi, \{Seyed Mohammad\}",

year = "2016",

month = nov,

day = "1",

doi = "10.1016/j.arr.2016.07.004",

language = "English",

volume = "31",

pages = "55--66",

journal = "Ageing Research Reviews",

issn = "1568-1637",

publisher = "Elsevier",

}

TY - JOUR

T1 - Targeting mTOR signaling by polyphenols

T2 - a new therapeutic target for ageing

AU - Pazoki-Toroudi, Hamidreza

AU - Amani, Hamed

AU - Ajami, Marjan

AU - Nabavi, Seyed Fazel

AU - Braidy, Nady

AU - Kasi, Pandima Devi

AU - Nabavi, Seyed Mohammad

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Current ageing research is aimed not only at the promotion of longevity, but also at improving ‎health span‎ through the‎ discovery and development‎ of new therapeutic strategies‎‏‎ by investigating ‎molecular and ‎cellular ‎pathways involved in cellular senescence.‎ Understanding the mechanism of action ‎of ‎polyphenolic compounds targeting mTOR (mechanistic target of rapamycin) and related pathways opens up new directions ‎‎to revolutionize ways to slow down the ‎onset and development of age-dependent degeneration. Herein, we will ‎discuss the mechanisms by which polyphenols can delay the‎ molecular ‎pathogenesis of ageing via manipulation or more specifically inhibition of mTOR-signaling pathways. We will also discuss the implications of polyphenols in targeting mTOR and its related ‎pathways‎‎ on ‎health life span extension and longevity.‎

AB - Current ageing research is aimed not only at the promotion of longevity, but also at improving ‎health span‎ through the‎ discovery and development‎ of new therapeutic strategies‎‏‎ by investigating ‎molecular and ‎cellular ‎pathways involved in cellular senescence.‎ Understanding the mechanism of action ‎of ‎polyphenolic compounds targeting mTOR (mechanistic target of rapamycin) and related pathways opens up new directions ‎‎to revolutionize ways to slow down the ‎onset and development of age-dependent degeneration. Herein, we will ‎discuss the mechanisms by which polyphenols can delay the‎ molecular ‎pathogenesis of ageing via manipulation or more specifically inhibition of mTOR-signaling pathways. We will also discuss the implications of polyphenols in targeting mTOR and its related ‎pathways‎‎ on ‎health life span extension and longevity.‎

KW - Journal Article

KW - Review

UR - https://www.scopus.com/pages/publications/84979743554

U2 - 10.1016/j.arr.2016.07.004

DO - 10.1016/j.arr.2016.07.004

M3 - Review article

C2 - 27453478

AN - SCOPUS:84979743554

SN - 1568-1637

VL - 31

SP - 55

EP - 66

JO - Ageing Research Reviews

JF - Ageing Research Reviews

ER -

Targeting mTOR signaling by polyphenols: a new therapeutic target for ageing

Abstract

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