Abstract
Intranasal delivery systems represent a compelling method for administering drugs directly to the central nervous system (CNS), circumventing the formidable blood-brain barrier (BBB). Anatomical, physiological, and technological aspects all influence the development of intranasal formulations aimed at brain targeting. The mechanisms enabling nose-to-brain delivery (N2B), the challenges inherent in formulating and deploying these systems, and recent advances in device technology that bolster drug bioavailability and patient adherence are discussed.
| Original language | English |
|---|---|
| Title of host publication | Respiratory Drug Delivery 2024 |
| Editors | R. N. Dalby, J. Peart, J. D. Suman, P. M. Young, D. Traini, A. Watts |
| Place of Publication | United States |
| Publisher | RDD Online |
| Pages | 66-72 |
| Number of pages | 7 |
| ISBN (Electronic) | 9781739682125 |
| Publication status | Published - 2024 |
| Event | Respiratory Drug Delivery 2024: RDD 2024 - Tuscon, United States Duration: 5 May 2024 → 9 May 2024 |
Conference
| Conference | Respiratory Drug Delivery 2024 |
|---|---|
| Country/Territory | United States |
| City | Tuscon |
| Period | 5/05/24 → 9/05/24 |
Keywords
- nasal delivery
- nose-to-brain (N2B)
- olfactory transport