Teleost-type angiotensin is present in Australian lungfish, Neoceratodus forsteri

J. M P Joss*, Y. Itahara, T. X. Watanabe, K. Nakajima, Y. Takei

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Angiotensin I (ANG I) was produced from the incubation of lungfish plasma with homologous kidney extracts. The purified peptide was found to have the sequence of H-Asn-Arg-Val-Tyr-Val-His-Pro-Phe-Thr-Leu-OH, which is homologous for the first eight residues with all teleost angiotensins so far sequenced, although lungfish generally possess tetrapod-type hormones. The lungfish decapeptide (ANG I) induced dose-dependent increases in arterial pressure in the rat. The lungfish octapeptide (ANG II) released aldosterone from kidney-adrenal tissue in vitro in a dose-dependent manner and induced dose-dependent increases in arterial pressure of the lung fish. Substitution of asparagine with aspartic acid in the first position (tetrapod-type ANG II) did not alter the blood pressure response significantly, but a second substitution of the valine in the (5)-position with isoleucine (ANG II form found in human and rat) abolished the rise in arterial pressure in lung fish over the same dose range.

Original languageEnglish
Pages (from-to)206-212
Number of pages7
JournalGeneral and Comparative Endocrinology
Volume114
Issue number2
DOIs
Publication statusPublished - 1999

Keywords

  • Aldosterone
  • Angiotensin
  • Lungfish
  • Neoceratodus
  • Vasopressor

Fingerprint Dive into the research topics of 'Teleost-type angiotensin is present in Australian lungfish, Neoceratodus forsteri'. Together they form a unique fingerprint.

  • Cite this