Temperature-dependent optical properties of Intralipid ® measured with frequency-domain photon-migration spectroscopy

Biju Cletus, Rainer Künnemeyer, Paul Martinsen, Vincent Andrew McGlone

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31 Citations (Scopus)


We present the temperature dependence of absorption and reduced scattering coefficients of 1.8% Intralipid measured by frequency-domain photon-migration spectroscopy between 710 and 850nm. These measurements were made in the physiologically relevant 30 to 40°C temperature range. The temperature coefficients for absorption were consistent during heating and cooling and follow closely other reported results. The change in absorption coefficient at 740nm suggests that a minimum temperature change of 4°C is observable within the error limits. We found that the reduced scattering coefficient shows a hysteresis with temperature at 740nm. The temperature coefficient for reduced scattering determined from heating cycle measurements agrees with theory and other measurements within the error limits.
Original languageEnglish
Pages (from-to)017003-1-017003-6
Number of pages6
JournalJournal of Biomedical Optics
Issue number1
Publication statusPublished - 2010
Externally publishedYes


  • frequency-domain spectroscopy
  • photon migration
  • absorption
  • reduced scattering
  • intralipid
  • temperature measurement


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