Teratological evaluation of 3-(di-2-thienylmethylene)-5-methyl-trans-quinolizidinium bromide in Japanese white rabbits

Y. Takayama, A. Matsuda, T. Tsuruzaki

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    Abstract

    From the results of the preliminary examination, the maximum safe dose was determined to be 300 mg/kg b.wt./day. Five dose groups were prepared based upon the maximum safe dose. The drug was administered through a stomach catheter to pregnant rabbits from days 6 to 18 of gestation, and fetuses were examined on day 29 of the pregnancies. No undesirable influence on the reproductive performance of the mother was found throughout the experiment. Effects of the treatment on the fetuses were a decrease of fetal weight and incomplete ossification. As regards congenital abnormalities, some internal and external malformations were observed in experimental as well as control groups, but no significant differences was detected. The results, therefore, suggest that the drug is not teratogenic, at least within the maximum safe dose.

    Original languageEnglish
    Pages (from-to)7-16
    Number of pages10
    JournalActa Medica et Biologica
    Volume28
    Issue number1
    Publication statusPublished - 1980

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