From the results of the preliminary examination, the maximum safe dose was determined to be 300 mg/kg b.wt./day. Five dose groups were prepared based upon the maximum safe dose. The drug was administered through a stomach catheter to pregnant rabbits from days 6 to 18 of gestation, and fetuses were examined on day 29 of the pregnancies. No undesirable influence on the reproductive performance of the mother was found throughout the experiment. Effects of the treatment on the fetuses were a decrease of fetal weight and incomplete ossification. As regards congenital abnormalities, some internal and external malformations were observed in experimental as well as control groups, but no significant differences was detected. The results, therefore, suggest that the drug is not teratogenic, at least within the maximum safe dose.
|Number of pages||10|
|Journal||Acta Medica et Biologica|
|Publication status||Published - 1980|