The A, B and C's of silicone breast implants: anaplastic large cell lymphoma, biofilm and capsular contracture

Maria Mempin, Honghua Hu, Durdana Chowdhury, Anand Deva, Karen Vickery

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Breast implantation either for cosmetic or reconstructive e purposes is one of the most common procedures performed in plastic surgery. Biofilm infection is hypothesised to be involved in the development of both capsular contracture and anaplastic large cell lymphoma (ALCL). Capsular contracture is one of the principal reasons for breast revision surgery and is characterised by the tightening and hardening of the capsule surrounding the implant, and ALCL is an indolent lymphoma found only in women with textured implants. We describe the types of breast implants available with regard to their surface characteristics of surface area and roughness and how this might contribute to capsular contracture and/or biofilm formation. The pathogenesis of capsular contracture is thought to be due to biofilm formation on the implant, which results in on-going inflammation. We describe the current research into breast implant associated ALCL and how implant properties may affect its pathogenesis, with ALCL only occurring in women with textured implants.

LanguageEnglish
Article number2393
Pages1-11
Number of pages11
JournalMaterials
Volume11
Issue number12
DOIs
Publication statusPublished - 28 Nov 2018

Fingerprint

Biofilms
Silicones
Surgery
Cosmetics
Capsules
Hardening
Surface roughness

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Anaplastic large cell lymphoma
  • BIA-ALCL
  • Biofilm
  • Breast implant
  • Textured: capsular contracture

Cite this

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title = "The A, B and C's of silicone breast implants: anaplastic large cell lymphoma, biofilm and capsular contracture",
abstract = "Breast implantation either for cosmetic or reconstructive e purposes is one of the most common procedures performed in plastic surgery. Biofilm infection is hypothesised to be involved in the development of both capsular contracture and anaplastic large cell lymphoma (ALCL). Capsular contracture is one of the principal reasons for breast revision surgery and is characterised by the tightening and hardening of the capsule surrounding the implant, and ALCL is an indolent lymphoma found only in women with textured implants. We describe the types of breast implants available with regard to their surface characteristics of surface area and roughness and how this might contribute to capsular contracture and/or biofilm formation. The pathogenesis of capsular contracture is thought to be due to biofilm formation on the implant, which results in on-going inflammation. We describe the current research into breast implant associated ALCL and how implant properties may affect its pathogenesis, with ALCL only occurring in women with textured implants.",
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The A, B and C's of silicone breast implants : anaplastic large cell lymphoma, biofilm and capsular contracture. / Mempin, Maria; Hu, Honghua; Chowdhury, Durdana; Deva, Anand; Vickery, Karen.

In: Materials, Vol. 11, No. 12, 2393, 28.11.2018, p. 1-11.

Research output: Contribution to journalReview articleResearchpeer-review

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